(+/-)-N-<(3-hydroxy-4-methoxyphenyl)acetyl>-3-methoxytyrosine methyl ester

Base Information

• Chemical Name: (+/-)-N-<(3-hydroxy-4-methoxyphenyl)acetyl>-3-methoxytyrosine methyl ester
• CAS No.: 113948-29-1
• Molecular Formula: C₂₀H₂₃NO₇
• Molecular Weight: 389.405
• Mol file: 113948-29-1.mol

Synonyms:(+/-)-N-<(3-hydroxy-4-methoxyphenyl)acetyl>-3-methoxytyrosine methyl ester

Chemical Property of (+/-)-N-<(3-hydroxy-4-methoxyphenyl)acetyl>-3-methoxytyrosine methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-N-<(3-hydroxy-4-methoxyphenyl)acetyl>-3-methoxytyrosine methyl ester

There total 6 articles about (+/-)-N-<(3-hydroxy-4-methoxyphenyl)acetyl>-3-methoxytyrosine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-[2-(3-Benzyloxy-4-methoxy-phenyl)-acetylamino]-3-(4-hydroxy-3-methoxy-phenyl)-propionic acid methyl ester (113948-36-0) → (+/-)-N-<(3-hydroxy-4-methoxyphenyl)acetyl>-3-methoxytyrosine methyl ester (113948-29-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate; for 20h;

DOI:10.1021/jo00245a035

Reference yield:

2-[2-(3-Benzyloxy-4-methoxy-phenyl)-acetylamino]-3-(4-hydroxy-3-methoxy-phenyl)-propionic acid methyl ester (113948-36-0) → N-<(3-hydroxy-4-methoxyphenyl)acetyl>-3-methoxy-D-tyrosine methyl ester (113948-29-1,113948-40-6)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate; for 20h; Yield given;

DOI:10.1021/jo00245a035

Reference yield:

O-benzylhomoisovanillic acid (5487-33-2) → (+/-)-N-<(3-hydroxy-4-methoxyphenyl)acetyl>-3-methoxytyrosine methyl ester (113948-29-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) 1,1'-carbonyldiimidazole / 1.) THF, 0 deg C to RT, 2.5 h, 2.) 0 deg C, 4 h

2: 99 percent / H₂ / 10percent Pd/C / ethyl acetate / 20 h

With hydrogen; 1,1'-carbonyldiimidazole; palladium on activated charcoal; In ethyl acetate;

DOI:10.1021/jo00245a035

upstream raw materials:

2-[2-(3-Benzyloxy-4-methoxy-phenyl)-acetylamino]-3-(4-hydroxy-3-methoxy-phenyl)-propionic acid methyl ester

O-benzylhomoisovanillic acid

(+/-)-3-methoxytyrosine methyl ester

2-[2-(3-Benzyloxy-4-methoxy-phenyl)-acetylamino]-3-(4-hydroxy-3-methoxy-phenyl)-propionic acid methyl ester

Downstream raw materials:

(+/-)-cis-1-<(3-hydroxy-4-methoxyphenyl)methyl>-3,4-dihydro-7-hydroxy-6-methoxy-2,3(1H)-isoquinolinedicarboxylic acid dimethyl ester