1-{4-[3-Bromo-4-(4-iodo-butoxy)-5-methyl-phenyl]-4-[3,5-dimethyl-4-(2-nitro-benzyloxy)-phenyl]-piperidin-1-yl}-ethanone

Base Information

Chemical Name:1-{4-[3-Bromo-4-(4-iodo-butoxy)-5-methyl-phenyl]-4-[3,5-dimethyl-4-(2-nitro-benzyloxy)-phenyl]-piperidin-1-yl}-ethanone
CAS No.:180892-01-7
Molecular Formula:C₃₃H₃₈BrIN₂O₅
Molecular Weight:749.484
Hs Code.:

Synonyms:1-{4-[3-Bromo-4-(4-iodo-butoxy)-5-methyl-phenyl]-4-[3,5-dimethyl-4-(2-nitro-benzyloxy)-phenyl]-piperidin-1-yl}-ethanone

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Chemical Property of 1-{4-[3-Bromo-4-(4-iodo-butoxy)-5-methyl-phenyl]-4-[3,5-dimethyl-4-(2-nitro-benzyloxy)-phenyl]-piperidin-1-yl}-ethanone

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Technology Process of 1-{4-[3-Bromo-4-(4-iodo-butoxy)-5-methyl-phenyl]-4-[3,5-dimethyl-4-(2-nitro-benzyloxy)-phenyl]-piperidin-1-yl}-ethanone

There total 5 articles about 1-{4-[3-Bromo-4-(4-iodo-butoxy)-5-methyl-phenyl]-4-[3,5-dimethyl-4-(2-nitro-benzyloxy)-phenyl]-piperidin-1-yl}-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 628-21-7
1,4-Diiodobutane

: 180892-00-6
1-{4-(3-Bromo-4-hydroxy-5-methyl-phenyl)-4-[3,5-dimethyl-4-(2-nitro-benzyloxy)-phenyl]-piperidin-1-yl}-ethanone

: 180892-01-7
1-{4-[3-Bromo-4-(4-iodo-butoxy)-5-methyl-phenyl]-4-[3,5-dimethyl-4-(2-nitro-benzyloxy)-phenyl]-piperidin-1-yl}-ethanone

Guidance literature:: With 2,6-di-tert-butyl-4-methyl-phenol; potassium carbonate; In acetone; Heating;

Reference yield:

: 125188-15-0
1-acetyl-4-(4-methoxy-3,5-dimethylphenyl)piperidin-4-ol

: 180892-01-7
1-{4-[3-Bromo-4-(4-iodo-butoxy)-5-methyl-phenyl]-4-[3,5-dimethyl-4-(2-nitro-benzyloxy)-phenyl]-piperidin-1-yl}-ethanone

Guidance literature:: Multi-step reaction with 5 steps

1: 93 percent / BBr₃ / CH₂Cl₂ / 3 h / Heating

2: 98 percent / K₂CO₃ / acetonitrile / 5 h / Heating

3: 93 percent / BF₃*OEt₂ / CH₂Cl₂ / 24 h / 50 °C

4: 92 percent / Br₂ / CH₂Cl₂ / 0.33 h / 0 °C

5: 91 percent / K₂CO₃, 2,6-di(tert-butyl)-4-methylphenol / acetone / 4 h / Heating

With 2,6-di-tert-butyl-4-methyl-phenol; boron trifluoride diethyl etherate; bromine; boron tribromide; potassium carbonate; In dichloromethane; acetone; acetonitrile;
DOI:10.1002/hlca.19970800516

Reference yield:

: 180891-98-9
1-{4-[3,5-Dimethyl-4-(2-nitro-benzyloxy)-phenyl]-3,6-dihydro-2H-pyridin-1-yl}-ethanone

: 180892-01-7
1-{4-[3-Bromo-4-(4-iodo-butoxy)-5-methyl-phenyl]-4-[3,5-dimethyl-4-(2-nitro-benzyloxy)-phenyl]-piperidin-1-yl}-ethanone

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / BF₃*OEt₂ / CH₂Cl₂ / 24 h / 50 °C

2: 92 percent / Br₂ / CH₂Cl₂ / 0.33 h / 0 °C

3: 91 percent / K₂CO₃, 2,6-di(tert-butyl)-4-methylphenol / acetone / 4 h / Heating

With 2,6-di-tert-butyl-4-methyl-phenol; boron trifluoride diethyl etherate; bromine; potassium carbonate; In dichloromethane; acetone;
DOI:10.1002/hlca.19970800516