18F-(R)-5-chloro-1-(1-cyclopropyl-2-methoxyethyl)-3-(4-(2-fluoroethoxy)-2,5-dimethyl phenylamino)pyrazin-2(1H)-one

Base Information

• Chemical Name: 18F-(R)-5-chloro-1-(1-cyclopropyl-2-methoxyethyl)-3-(4-(2-fluoroethoxy)-2,5-dimethyl phenylamino)pyrazin-2(1H)-one
• CAS No.: 1408250-51-0
• Molecular Formula: C₂₀H₂₅ClFN₃O₃
• Molecular Weight: 408.89
• Mol file: 1408250-51-0.mol

Synonyms:18F-(R)-5-chloro-1-(1-cyclopropyl-2-methoxyethyl)-3-(4-(2-fluoroethoxy)-2,5-dimethyl phenylamino)pyrazin-2(1H)-one

Chemical Property of 18F-(R)-5-chloro-1-(1-cyclopropyl-2-methoxyethyl)-3-(4-(2-fluoroethoxy)-2,5-dimethyl phenylamino)pyrazin-2(1H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 18F-(R)-5-chloro-1-(1-cyclopropyl-2-methoxyethyl)-3-(4-(2-fluoroethoxy)-2,5-dimethyl phenylamino)pyrazin-2(1H)-one

There total 3 articles about 18F-(R)-5-chloro-1-(1-cyclopropyl-2-methoxyethyl)-3-(4-(2-fluoroethoxy)-2,5-dimethyl phenylamino)pyrazin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-5-chloro-1-(1-cyclopropyl-2-methoxyethyl)-3-(4-hydroxy-2,5-dimethylphenylamino)pyrazin-2(1H)-one (1173523-81-3) + 1-bromo-2-[18F]fluoroethane (85725-77-5) → 18F-(R)-5-chloro-1-(1-cyclopropyl-2-methoxyethyl)-3-(4-(2-fluoroethoxy)-2,5-dimethyl phenylamino)pyrazin-2(1H)-one (1408250-51-0)

Guidance literature:

With dimethyl sulfoxide; potassium hydroxide; In water; at 60 - 70 ℃; for 0.2h;

DOI:10.1016/j.bmcl.2012.08.112

Reference yield:

(R)-3,5-dichloro-1-(1-cyclopropyl-2-methoxyethyl)pyrazin-2(1H)-one (1173435-16-9) → 18F-(R)-5-chloro-1-(1-cyclopropyl-2-methoxyethyl)-3-(4-(2-fluoroethoxy)-2,5-dimethyl phenylamino)pyrazin-2(1H)-one (1408250-51-0)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hexamethyldisilazane / tetrahydrofuran

2: boron tribromide / dichloromethane / -78 °C

3: potassium hydroxide; dimethyl sulfoxide / water / 0.2 h / 60 - 70 °C

With sodium hexamethyldisilazane; boron tribromide; dimethyl sulfoxide; potassium hydroxide; In tetrahydrofuran; dichloromethane; water;

DOI:10.1016/j.bmcl.2012.08.112

Reference yield:

4-methoxy-2,5-dimethylaniline (117174-70-6) → 18F-(R)-5-chloro-1-(1-cyclopropyl-2-methoxyethyl)-3-(4-(2-fluoroethoxy)-2,5-dimethyl phenylamino)pyrazin-2(1H)-one (1408250-51-0)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hexamethyldisilazane / tetrahydrofuran

2: boron tribromide / dichloromethane / -78 °C

3: potassium hydroxide; dimethyl sulfoxide / water / 0.2 h / 60 - 70 °C

With sodium hexamethyldisilazane; boron tribromide; dimethyl sulfoxide; potassium hydroxide; In tetrahydrofuran; dichloromethane; water;

DOI:10.1016/j.bmcl.2012.08.112

upstream raw materials:

(R)-5-chloro-1-(1-cyclopropyl-2-methoxyethyl)-3-(4-hydroxy-2,5-dimethylphenylamino)pyrazin-2(1H)-one

1-bromo-2-[¹⁸F]fluoroethane

(R)-3,5-dichloro-1-(1-cyclopropyl-2-methoxyethyl)pyrazin-2(1H)-one

4-methoxy-2,5-dimethylaniline