2-(4-((3-(4-methoxybenzyl)-2-(4-methoxybenzylimino)-4-oxothiazolidin-5-ylidene)methyl) phenoxy)acetic acid

Base Information

• Chemical Name: 2-(4-((3-(4-methoxybenzyl)-2-(4-methoxybenzylimino)-4-oxothiazolidin-5-ylidene)methyl) phenoxy)acetic acid
• CAS No.: 1280722-98-6
• Molecular Formula: C₂₈H₂₆N₂O₆S
• Molecular Weight: 518.59
• Mol file: 1280722-98-6.mol

Synonyms:2-(4-((3-(4-methoxybenzyl)-2-(4-methoxybenzylimino)-4-oxothiazolidin-5-ylidene)methyl) phenoxy)acetic acid

Chemical Property of 2-(4-((3-(4-methoxybenzyl)-2-(4-methoxybenzylimino)-4-oxothiazolidin-5-ylidene)methyl) phenoxy)acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-((3-(4-methoxybenzyl)-2-(4-methoxybenzylimino)-4-oxothiazolidin-5-ylidene)methyl) phenoxy)acetic acid

There total 4 articles about 2-(4-((3-(4-methoxybenzyl)-2-(4-methoxybenzylimino)-4-oxothiazolidin-5-ylidene)methyl) phenoxy)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

5-(4-hydroxybenzylidene)-3-(4-methoxybenzyl)-2-(4-methoxybenzylimino)thiazolidin-4-one (1280722-96-4) + bromoacetic acid methyl ester (96-32-2) → 2-(4-((3-(4-methoxybenzyl)-2-(4-methoxybenzylimino)-4-oxothiazolidin-5-ylidene)methyl) phenoxy)acetic acid (1280722-98-6)

Guidance literature:

5-(4-hydroxybenzylidene)-3-(4-methoxybenzyl)-2-(4-methoxybenzylimino)thiazolidin-4-one; bromoacetic acid methyl ester; With potassium carbonate; In acetone; for 6h; Reflux;

With potassium carbonate; In methanol; water; for 12h; Reflux;

DOI:10.1016/j.ejmech.2010.12.014

Reference yield:

1,3-bis(4-methoxyphenylmethyl)thiourea (22313-70-8) → 2-(4-((3-(4-methoxybenzyl)-2-(4-methoxybenzylimino)-4-oxothiazolidin-5-ylidene)methyl) phenoxy)acetic acid (1280722-98-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium acetate / Reflux

2.1: piperidine / ethanol / 6 h / Reflux

3.1: potassium carbonate / acetone / 6 h / Reflux

3.2: 12 h / Reflux

With piperidine; sodium acetate; potassium carbonate; In ethanol; acetone;

DOI:10.1016/j.ejmech.2010.12.014

Reference yield:

C19H20N2O3S (1280722-91-9) → 2-(4-((3-(4-methoxybenzyl)-2-(4-methoxybenzylimino)-4-oxothiazolidin-5-ylidene)methyl) phenoxy)acetic acid (1280722-98-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: piperidine / ethanol / 6 h / Reflux

2.1: potassium carbonate / acetone / 6 h / Reflux

2.2: 12 h / Reflux

With piperidine; potassium carbonate; In ethanol; acetone;

DOI:10.1016/j.ejmech.2010.12.014

upstream raw materials:

C₁₉H₂₀N₂O₃S

5-(4-hydroxybenzylidene)-3-(4-methoxybenzyl)-2-(4-methoxybenzylimino)thiazolidin-4-one

bromoacetic acid methyl ester

1,3-bis(4-methoxyphenylmethyl)thiourea