Methyl-(3-nitro-2-phenyl-propyl)-carbamic acid tert-butyl ester

Base Information

• Chemical Name: Methyl-(3-nitro-2-phenyl-propyl)-carbamic acid tert-butyl ester
• CAS No.: 161804-76-8
• Molecular Formula: C₁₅H₂₂N₂O₄
• Molecular Weight: 294.351
• Mol file: 161804-76-8.mol

Synonyms:Methyl-(3-nitro-2-phenyl-propyl)-carbamic acid tert-butyl ester

Chemical Property of Methyl-(3-nitro-2-phenyl-propyl)-carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of Methyl-(3-nitro-2-phenyl-propyl)-carbamic acid tert-butyl ester

There total 1 articles about Methyl-(3-nitro-2-phenyl-propyl)-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

nitrostyrene (5153-67-3) + C7H14BrMgNO2 → Methyl-(3-nitro-2-phenyl-propyl)-carbamic acid tert-butyl ester (161804-76-8)

Guidance literature:

at -78 ℃; for 1h;

DOI:10.1016/0040-4039(94)02228-4

Reference yield: 92.0%

Methyl-(3-nitro-2-phenyl-propyl)-carbamic acid tert-butyl ester (161804-76-8) → Methyl-(3-nitro-2-phenyl-propyl)-amine

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 25 ℃; for 1h;

DOI:10.1016/0040-4039(94)02228-4

Reference yield: 80.0%

Methyl-(3-nitro-2-phenyl-propyl)-carbamic acid tert-butyl ester (161804-76-8) → (2-Amino-cyclohexylmethyl)-methyl-carbamic acid tert-butyl ester (161804-68-8)

Guidance literature:

With hydrogen; platinum(IV) oxide; In ethanol; at 25 ℃; for 12h; under 760 Torr;

DOI:10.1016/0040-4039(94)02228-4

upstream raw materials:

nitrostyrene

Downstream raw materials:

(2-Amino-cyclohexylmethyl)-methyl-carbamic acid tert-butyl ester

(3-Amino-2-phenyl-propyl)-methyl-carbamic acid tert-butyl ester

Methyl-[2-(2-naphthalen-2-yl-quinolin-4-ylamino)-cyclohexylmethyl]-carbamic acid tert-butyl ester

Methyl-[3-(2-naphthalen-2-yl-quinolin-4-ylamino)-2-phenyl-propyl]-carbamic acid tert-butyl ester