benzyl (2R)-2-<4-<4-(2,2,3,3-tetrafluoropropoxy)phenyl>-4,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl>propanoate

Base Information

Chemical Name:benzyl (2R)-2-<4-<4-(2,2,3,3-tetrafluoropropoxy)phenyl>-4,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl>propanoate
CAS No.:174563-09-8
Molecular Formula:C₂₁H₁₉F₄N₃O₄
Molecular Weight:453.393
Hs Code.:

Synonyms:benzyl (2R)-2-<4-<4-(2,2,3,3-tetrafluoropropoxy)phenyl>-4,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl>propanoate

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Chemical Property of benzyl (2R)-2-<4-<4-(2,2,3,3-tetrafluoropropoxy)phenyl>-4,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl>propanoate

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Technology Process of benzyl (2R)-2-<4-<4-(2,2,3,3-tetrafluoropropoxy)phenyl>-4,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl>propanoate

There total 2 articles about benzyl (2R)-2-<4-<4-(2,2,3,3-tetrafluoropropoxy)phenyl>-4,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl>propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 56777-24-3
benzyl (S)-Lactate

: 174563-09-8
benzyl (2R)-2-<4-<4-(2,2,3,3-tetrafluoropropoxy)phenyl>-4,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl>propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / i-Pr₂NEt / CH₂Cl₂ / 0.17 h / -25 °C

2: 1.) NaH / 1.) DMF, RT, 40 min, 2.) DMF, THF, -30 deg C, 10 min

With sodium hydride; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1248/cpb.47.360

Reference yield:

: 93836-48-7
(S)-2-(trifluoromethanesulphonyloxy)propionic acid benzyl ester

: 155431-64-4
4-<4-(2,2,3,3-tetrafluoropropoxy)phenyl>-3(2H,4H)-1,2,4-triazolone

: 174563-09-8
benzyl (2R)-2-<4-<4-(2,2,3,3-tetrafluoropropoxy)phenyl>-4,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl>propanoate

: (S)-2-{5-Oxo-4-[4-(2,2,3,3-tetrafluoro-propoxy)-phenyl]-4,5-dihydro-[1,2,4]triazol-1-yl}-propionic acid benzyl ester

Guidance literature:: With sodium hydride; Yield given; Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts; 1.) DMF, RT, 40 min, 2.) DMF, THF, -30 deg C, 10 min;
DOI:10.1248/cpb.47.360