phosphoric acid, (+/-)-3,3-difluoro-2-octyloxymethyl-4-oxoeicosyl diphenyl ester

Base Information

Chemical Name:phosphoric acid, (+/-)-3,3-difluoro-2-octyloxymethyl-4-oxoeicosyl diphenyl ester
CAS No.:111958-60-2
Molecular Formula:C₄₁H₆₅F₂O₆P
Molecular Weight:722.934
Hs Code.:

Synonyms:phosphoric acid, (+/-)-3,3-difluoro-2-octyloxymethyl-4-oxoeicosyl diphenyl ester

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Chemical Property of phosphoric acid, (+/-)-3,3-difluoro-2-octyloxymethyl-4-oxoeicosyl diphenyl ester

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Technology Process of phosphoric acid, (+/-)-3,3-difluoro-2-octyloxymethyl-4-oxoeicosyl diphenyl ester

There total 10 articles about phosphoric acid, (+/-)-3,3-difluoro-2-octyloxymethyl-4-oxoeicosyl diphenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: phosphoric acid, (R*,R*)- and (R*,S*)-3,3-difluoro-2-octyloxymethyl-4-hydroxyeicosyl diphenyl ester

: 111958-60-2
phosphoric acid, (+/-)-3,3-difluoro-2-octyloxymethyl-4-oxoeicosyl diphenyl ester

Guidance literature:: With dipyridine chromium trioxide; In dichloromethane; at 25 ℃;
DOI:10.1021/ja00260a020

Reference yield:

: 16156-52-8
n-octyl methanesulfonate

: 111958-60-2
phosphoric acid, (+/-)-3,3-difluoro-2-octyloxymethyl-4-oxoeicosyl diphenyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 72 percent / NaH / tetrahydrofuran / 1.) RT, 1.5 h; 2.) reflux, 20 h; 3.) RT, 10 h

2: 5percent NaH / tetrahydrofuran / 2 h / -5 °C

3: n-BuLi / tetrahydrofuran / -60 °C

4: H₂O / 25 °C

5: diethyl ether / 25 °C

6: 58 percent / diethyl ether / -70 °C

7: 1.) O₃; 2.) NaBH₄ / 1.) MeOH, -70 deg C; 2.) MeOH, -70 deg C

8: 98 percent / pyridine / 25 °C

9: 76 percent / CrO₃(pyridine)2 / CH₂Cl₂ / 25 °C

With pyridine; sodium tetrahydroborate; n-butyllithium; water; dipyridine chromium trioxide; sodium hydride; ozone; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/ja00260a020

Reference yield:

: 65018-36-2
hexadecyllithium

: 111958-60-2
phosphoric acid, (+/-)-3,3-difluoro-2-octyloxymethyl-4-oxoeicosyl diphenyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 58 percent / diethyl ether / -70 °C

2: 1.) O₃; 2.) NaBH₄ / 1.) MeOH, -70 deg C; 2.) MeOH, -70 deg C

3: 98 percent / pyridine / 25 °C

4: 76 percent / CrO₃(pyridine)2 / CH₂Cl₂ / 25 °C

With pyridine; sodium tetrahydroborate; dipyridine chromium trioxide; ozone; In diethyl ether; dichloromethane;
DOI:10.1021/ja00260a020