10-(4-dimethylamino-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-4-ethyl-11-methoxy-3a,7,9,11,13,15-hexamethyl-1-(4-phenyl-but-2-enyl)-octahydro-3,5-dioxa-1-aza-cyclopentacyclotetradecene-2,6,8,14-tetraone 14-(O-piperidin-3-yl-oxime)

Base Information

Chemical Name:10-(4-dimethylamino-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-4-ethyl-11-methoxy-3a,7,9,11,13,15-hexamethyl-1-(4-phenyl-but-2-enyl)-octahydro-3,5-dioxa-1-aza-cyclopentacyclotetradecene-2,6,8,14-tetraone 14-(O-piperidin-3-yl-oxime)
CAS No.:574743-50-3
Molecular Formula:C₄₆H₇₂N₄O₁₀
Molecular Weight:841.098
Hs Code.:

10-(4-dimethylamino-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-4-ethyl-11-methoxy-3a,7,9,11,13,15-hexamethyl-1-(4-phenyl-but-2-enyl)-octahydro-3,5-dioxa-1-aza-cyclopentacyclotetradecene-2,6,8,14-tetraone 14-(<i>O</i>-piperidin-3-yl-oxime)

Synonyms:10-(4-dimethylamino-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-4-ethyl-11-methoxy-3a,7,9,11,13,15-hexamethyl-1-(4-phenyl-but-2-enyl)-octahydro-3,5-dioxa-1-aza-cyclopentacyclotetradecene-2,6,8,14-tetraone 14-(O-piperidin-3-yl-oxime)

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Chemical Property of 10-(4-dimethylamino-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-4-ethyl-11-methoxy-3a,7,9,11,13,15-hexamethyl-1-(4-phenyl-but-2-enyl)-octahydro-3,5-dioxa-1-aza-cyclopentacyclotetradecene-2,6,8,14-tetraone 14-(O-piperidin-3-yl-oxime)

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Technology Process of 10-(4-dimethylamino-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-4-ethyl-11-methoxy-3a,7,9,11,13,15-hexamethyl-1-(4-phenyl-but-2-enyl)-octahydro-3,5-dioxa-1-aza-cyclopentacyclotetradecene-2,6,8,14-tetraone 14-(O-piperidin-3-yl-oxime)

There total 9 articles about 10-(4-dimethylamino-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-4-ethyl-11-methoxy-3a,7,9,11,13,15-hexamethyl-1-(4-phenyl-but-2-enyl)-octahydro-3,5-dioxa-1-aza-cyclopentacyclotetradecene-2,6,8,14-tetraone 14-(O-piperidin-3-yl-oxime) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 574743-49-0
C₅₆H₈₈N₄O₁₄

: 574743-50-3
10-(4-dimethylamino-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-4-ethyl-11-methoxy-3a,7,9,11,13,15-hexamethyl-1-(4-phenyl-but-2-enyl)-octahydro-3,5-dioxa-1-aza-cyclopentacyclotetradecene-2,6,8,14-tetraone 14-(O-piperidin-3-yl-oxime)

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1016/S0968-0896(03)00147-0

Reference yield:

: 172822-30-9
(3aS,4R,7R,9R,10R,11R,13R,15R,15aR)-1-Amino-10-((2S,3R,4S,6R)-4-dimethylamino-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-4-ethyl-11-methoxy-3a,7,9,11,13,15-hexamethyl-octahydro-3,5-dioxa-1-aza-cyclopentacyclotetradecene-2,6,8,14-tetraone

: 574743-50-3
10-(4-dimethylamino-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-4-ethyl-11-methoxy-3a,7,9,11,13,15-hexamethyl-1-(4-phenyl-but-2-enyl)-octahydro-3,5-dioxa-1-aza-cyclopentacyclotetradecene-2,6,8,14-tetraone 14-(O-piperidin-3-yl-oxime)

Guidance literature:: Multi-step reaction with 8 steps

1: 77 percent / HCl / ethanol / 144 h / pH 4 / Heating

2: 42 percent / glycolaldehyde dimer; acetic acid / CH₂Cl₂ / 12 h / 20 °C

3: 93 percent / CH₂Cl₂ / 3 h / 20 °C

4: cyclohexene / palladium hydroxide / dioxane / 24 h / 80 °C

5: 0.866 g / triethylamine; 4-N,N-dimethyl-amino-pyridine / tetrahydrofuran / 24 h / 20 °C

6: 65 percent / sodium hydride / 1,2-dimethoxy-ethane; various solvent(s) / 3 h / 20 °C

7: CH₃OH / 4 h / 20 °C

8: trifluoroacetic acid / CH₂Cl₂ / 2 h / 20 °C

With glycolaldehyde dimer; hydrogenchloride; methanol; dmap; sodium hydride; acetic acid; triethylamine; trifluoroacetic acid; cyclohexene; palladium dihydroxide; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; ethanol; dichloromethane;
DOI:10.1016/S0968-0896(03)00147-0

Reference yield:

: 227614-36-0
(3R)-(aminooxy)-1-(carbobenzyloxy)piperidine

: 574743-50-3
10-(4-dimethylamino-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-4-ethyl-11-methoxy-3a,7,9,11,13,15-hexamethyl-1-(4-phenyl-but-2-enyl)-octahydro-3,5-dioxa-1-aza-cyclopentacyclotetradecene-2,6,8,14-tetraone 14-(O-piperidin-3-yl-oxime)

Guidance literature:: Multi-step reaction with 8 steps

1: 77 percent / HCl / ethanol / 144 h / pH 4 / Heating

2: 42 percent / glycolaldehyde dimer; acetic acid / CH₂Cl₂ / 12 h / 20 °C

3: 93 percent / CH₂Cl₂ / 3 h / 20 °C

4: cyclohexene / palladium hydroxide / dioxane / 24 h / 80 °C

5: 0.866 g / triethylamine; 4-N,N-dimethyl-amino-pyridine / tetrahydrofuran / 24 h / 20 °C

6: 65 percent / sodium hydride / 1,2-dimethoxy-ethane; various solvent(s) / 3 h / 20 °C

7: CH₃OH / 4 h / 20 °C

8: trifluoroacetic acid / CH₂Cl₂ / 2 h / 20 °C

With glycolaldehyde dimer; hydrogenchloride; methanol; dmap; sodium hydride; acetic acid; triethylamine; trifluoroacetic acid; cyclohexene; palladium dihydroxide; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; ethanol; dichloromethane;
DOI:10.1016/S0968-0896(03)00147-0