[(S)-1-(2,3-Dihydro-benzo[1,4]oxathiin-2-yl)methyl]-[2-(2,6-dimethoxy-phenoxy)-ethyl]-amine

Base Information

• Chemical Name: [(S)-1-(2,3-Dihydro-benzo[1,4]oxathiin-2-yl)methyl]-[2-(2,6-dimethoxy-phenoxy)-ethyl]-amine
• CAS No.: 736160-94-4
• Molecular Formula: C₁₉H₂₃NO₄S
• Molecular Weight: 361.462
• Mol file: 736160-94-4.mol

Synonyms:[(S)-1-(2,3-Dihydro-benzo[1,4]oxathiin-2-yl)methyl]-[2-(2,6-dimethoxy-phenoxy)-ethyl]-amine

Chemical Property of [(S)-1-(2,3-Dihydro-benzo[1,4]oxathiin-2-yl)methyl]-[2-(2,6-dimethoxy-phenoxy)-ethyl]-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [(S)-1-(2,3-Dihydro-benzo[1,4]oxathiin-2-yl)methyl]-[2-(2,6-dimethoxy-phenoxy)-ethyl]-amine

There total 3 articles about [(S)-1-(2,3-Dihydro-benzo[1,4]oxathiin-2-yl)methyl]-[2-(2,6-dimethoxy-phenoxy)-ethyl]-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-2,3-Dihydro-benzo[1,4]oxathiine-2-carboxylic acid [2-(2,6-dimethoxy-phenoxy)-ethyl]-amide (92642-96-1,109912-68-7,109912-69-8) → [(S)-1-(2,3-Dihydro-benzo[1,4]oxathiin-2-yl)methyl]-[2-(2,6-dimethoxy-phenoxy)-ethyl]-amine (736160-94-4)

Guidance literature:

With dimethylsulfide borane complex; In diethylene glycol dimethyl ether; at 120 ℃; for 15h;

DOI:10.1016/0223-5234(87)90170-X

Reference yield:

2,3-dihydrobenzo[b][1,4]oxathiine-2-carboxylic acid (92642-95-0,109912-66-5,109912-67-6) → [(S)-1-(2,3-Dihydro-benzo[1,4]oxathiin-2-yl)methyl]-[2-(2,6-dimethoxy-phenoxy)-ethyl]-amine (736160-94-4)

Guidance literature:

Multi-step reaction with 3 steps

2: 1.) ethyl chlorocarbonate (EtOCOCl), Et₃N / 1.) THF, 0 deg C; 2.) THF, RT

3: 10M BH₃*MeSMe / bis-(2-methoxy-ethyl) ether / 15 h / 120 °C

With dimethylsulfide borane complex; chloroformic acid ethyl ester; triethylamine; In diethylene glycol dimethyl ether;

DOI:10.1016/0223-5234(87)90170-X

Reference yield:

(+)-1,4-benzoxathian-2-carboxylic acid (92642-95-0,109912-65-4,109912-66-5,109912-67-6) → [(S)-1-(2,3-Dihydro-benzo[1,4]oxathiin-2-yl)methyl]-[2-(2,6-dimethoxy-phenoxy)-ethyl]-amine (736160-94-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) ethyl chlorocarbonate (EtOCOCl), Et₃N / 1.) THF, 0 deg C; 2.) THF, RT

2: 10M BH₃*MeSMe / bis-(2-methoxy-ethyl) ether / 15 h / 120 °C

With dimethylsulfide borane complex; chloroformic acid ethyl ester; triethylamine; In diethylene glycol dimethyl ether;

DOI:10.1016/0223-5234(87)90170-X

upstream raw materials:

(R)-2,3-Dihydro-benzo[1,4]oxathiine-2-carboxylic acid [2-(2,6-dimethoxy-phenoxy)-ethyl]-amide

2,3-dihydrobenzo[b][1,4]oxathiine-2-carboxylic acid

(+)-1,4-benzoxathian-2-carboxylic acid