Technology Process of (1R,3aR,4S,7aR,1S)-7a-methyl-1-[(1S,2RS,4R)-4,5-dihydroxy-1,5-dimethyl-2-(phenylsulphonyl)hexyl]octahydro-1H-inden-4-ol
There total 2 articles about (1R,3aR,4S,7aR,1S)-7a-methyl-1-[(1S,2RS,4R)-4,5-dihydroxy-1,5-dimethyl-2-(phenylsulphonyl)hexyl]octahydro-1H-inden-4-ol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 98 percent / 4-dimethylaminopyridine; pyridine / CH2Cl2 / 16 h / 20 °C
2: 71 percent / n-BuLi / tetrahydrofuran; hexane / 2 h / -20 °C
With
pyridine; dmap; n-butyllithium;
In
tetrahydrofuran; hexane; dichloromethane;
DOI:10.1016/S0039-128X(00)00149-5
- Guidance literature:
-
Multi-step reaction with 11 steps
1: 97 percent / sodium amalgam / tetrahydrofuran; methanol / 15 h / 20 °C
2: TsOH / acetone / 15 h / 20 °C
3: pyridine; 4-dimethylaminopyridine / 4 h / 20 °C
4: 61 percent / I2 / methanol / 4.5 h / Heating
5: 92 percent / 2,6-lutidine / CH2Cl2 / 1.5 h / 20 °C
6: 96 percent / lithium aluminum hydride / tetrahydrofuran / 1.5 h
7: 96 percent / N-methylmorpholine N-oxide; 4A molecular sieves; tetrapropylammonium perruthenate / CH2Cl2 / 2.5 h / 20 °C
8: 100 percent / N-methylmorpholine N-oxide; 4A molecular sieves; tetrapropylammonium perruthenate / CH2Cl2 / 5 h / 20 °C
9: 57 percent / sodium hexamethyldilazide / tetrahydrofuran / 1 h / 20 °C
10: 34 percent / triphenylphosphine; tris(dibenzylideneacetone)dipalladium(0)*chloroform; triethylamine / toluene / 4 h / Heating
11: 60 percent / tetrabutylammonium fluoride / toluene / 2 h / 105 °C
With
pyridine; 2,6-dimethylpyridine; dmap; tris(dibenzylideneacetone)dipalladium(0) chloroform complex; sodium amalgam; lithium aluminium tetrahydride; tetrapropylammonium perruthennate; 4 A molecular sieve; tetrabutyl ammonium fluoride; iodine; sodium hexamethyldisilazane; toluene-4-sulfonic acid; 4-methylmorpholine N-oxide; triethylamine; triphenylphosphine;
In
tetrahydrofuran; methanol; dichloromethane; acetone; toluene;
DOI:10.1016/S0039-128X(00)00149-5
