(+/-)-α/β-9-(2-benzoyloxymethyl-1,3-oxaselenolan-5-yl)-6-chloro-2-fluoropurine

Base Information

Chemical Name:(+/-)-α/β-9-(2-benzoyloxymethyl-1,3-oxaselenolan-5-yl)-6-chloro-2-fluoropurine
CAS No.:305808-96-2
Molecular Formula:C₁₆H₁₂ClFN₄O₃Se
Molecular Weight:441.708
Hs Code.:

Synonyms:(+/-)-α/β-9-(2-benzoyloxymethyl-1,3-oxaselenolan-5-yl)-6-chloro-2-fluoropurine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+/-)-α/β-9-(2-benzoyloxymethyl-1,3-oxaselenolan-5-yl)-6-chloro-2-fluoropurine

Chemical Property:

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Technology Process of (+/-)-α/β-9-(2-benzoyloxymethyl-1,3-oxaselenolan-5-yl)-6-chloro-2-fluoropurine

There total 4 articles about (+/-)-α/β-9-(2-benzoyloxymethyl-1,3-oxaselenolan-5-yl)-6-chloro-2-fluoropurine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 149712-96-9
2-fluoro-6-chloropurine

: 194783-62-5
(+/-)-2-benzoyloxymethyl-1,2-oxaselenolane 5-acetate

: 305808-96-2
(+/-)-α/β-9-(2-benzoyloxymethyl-1,3-oxaselenolan-5-yl)-6-chloro-2-fluoropurine

Guidance literature:: With trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1021/jm990113x

Reference yield:

: 1651-29-2
6-chloro-2-fluoropurine

: 305808-96-2
(+/-)-α/β-9-(2-benzoyloxymethyl-1,3-oxaselenolan-5-yl)-6-chloro-2-fluoropurine

Guidance literature:: Multi-step reaction with 2 steps

1: (NH₄)2SO₄ / 4 h / Heating

2: TMSOTf / CH₂Cl₂ / 2 h / 20 °C

With ammonium sulfate; trimethylsilyl trifluoromethanesulfonate; In dichloromethane; 1: silylation / 2: Condensation;
DOI:10.1021/jm990113x

Reference yield:

: 1026241-79-1
Benzoic acid 5-hydroxy-[1,3]oxaselenolan-2-ylmethyl ester

: 305808-96-2
(+/-)-α/β-9-(2-benzoyloxymethyl-1,3-oxaselenolan-5-yl)-6-chloro-2-fluoropurine

Guidance literature:: Multi-step reaction with 2 steps

1: hexane; tetrahydrofuran / 3 h / 20 °C

2: TMSOTf / CH₂Cl₂ / 2 h / 20 °C

With trimethylsilyl trifluoromethanesulfonate; In tetrahydrofuran; hexane; dichloromethane; 1: Acetylation / 2: Condensation;
DOI:10.1021/jm990113x