3-[7-trifluoromethyl-5-(2-trifluoromethylphenyl)-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene

Base Information

Chemical Name:3-[7-trifluoromethyl-5-(2-trifluoromethylphenyl)-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene
CAS No.:1221349-53-6
Molecular Formula:C₂₃H₁₉F₆N₃O
Molecular Weight:467.414
Hs Code.:

Synonyms:3-[7-trifluoromethyl-5-(2-trifluoromethylphenyl)-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene

Suppliers and Price of 3-[7-trifluoromethyl-5-(2-trifluoromethylphenyl)-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
TC-I 2014
10mg
$ 475.00

Usbiological
TC-I 2014
1mg
$ 368.00

TRC
TC-I2014
2.5mg
$ 175.00

Tocris
TC-I2014 ≥98%(HPLC)
50
$ 909.00

Tocris
TC-I2014 ≥98%(HPLC)
10
$ 217.00

ChemScene
TC-I2014 >99.0%
5mg
$ 350.00

Total 2 raw suppliers

Chemical Property of 3-[7-trifluoromethyl-5-(2-trifluoromethylphenyl)-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene

Chemical Property:

Boiling Point:564.3±60.0 °C(Predicted)
Density:1.48±0.1 g/cm3(Predicted)

Purity/Quality:

99%, ^*data from raw suppliers

TC-I 2014 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses TC-I 2014 is a potent TRPM8 antagonist exhibiting antiallodynic properties in pain models.

Technology Process of 3-[7-trifluoromethyl-5-(2-trifluoromethylphenyl)-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene

There total 8 articles about 3-[7-trifluoromethyl-5-(2-trifluoromethylphenyl)-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1221349-87-6
1-oxa-2-aza-spiro[4.5]dec-2-ene-3-carboxylic acid (4-amino-5,2'-bis-trifluoromethyl-biphenyl-3-yl)-amide

: 1221349-53-6
3-[7-trifluoromethyl-5-(2-trifluoromethylphenyl)-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene

Guidance literature:: With camphor-10-sulfonic acid; In 1,4-dioxane; at 100 ℃; for 7.5h;

Reference yield:

: 1259026-33-9
1-oxa-2-aza-spiro[4.5]dec-2-ene-3-carboxylic acid chloride

: 1221349-86-5
5,2'-bis-trifluoromethyl-biphenyl-3,4-diamine

: 1221349-53-6
3-[7-trifluoromethyl-5-(2-trifluoromethylphenyl)-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene

Guidance literature:: 1-oxa-2-aza-spiro[4.5]dec-2-ene-3-carboxylic acid chloride; 5,2'-bis-trifluoromethyl-biphenyl-3,4-diamine; With triethylamine; In dichloromethane; at 20 ℃; for 2h;

With camphor-10-sulfonic acid; In 1,4-dioxane; at 100 ℃; for 3h;
DOI:10.1021/jm101075v

Reference yield:

: 1015770-74-7
1-oxa-2-aza-spiro[4.5]dec-2-ene-3-carboxylic acid ethyl ester

: 1221349-53-6
3-[7-trifluoromethyl-5-(2-trifluoromethylphenyl)-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hydrochloride monohydrate; water / methanol / 16 h / 20 °C

2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C

3.1: triethylamine / dichloromethane / 2 h / 20 °C

3.2: 3 h / 100 °C

With oxalyl dichloride; lithium hydrochloride monohydrate; water; triethylamine; N,N-dimethyl-formamide; In methanol; dichloromethane;
DOI:10.1021/jm101075v