9,10-dimethoxy-4-oxo-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinoline-6-carboselenoic acid Se-phenyl ester

Base Information

Chemical Name:9,10-dimethoxy-4-oxo-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinoline-6-carboselenoic acid Se-phenyl ester
CAS No.:909281-74-9
Molecular Formula:C₂₂H₂₃NO₄Se
Molecular Weight:444.389
Hs Code.:

9,10-dimethoxy-4-oxo-1,3,4,6,7,11b-hexahydro-2<i>H</i>-pyrido[2,1-<i>a</i>]isoquinoline-6-carboselenoic acid <i>Se</i>-phenyl ester

Synonyms:9,10-dimethoxy-4-oxo-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinoline-6-carboselenoic acid Se-phenyl ester

Suppliers and Price of 9,10-dimethoxy-4-oxo-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinoline-6-carboselenoic acid Se-phenyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 9,10-dimethoxy-4-oxo-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinoline-6-carboselenoic acid Se-phenyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 9,10-dimethoxy-4-oxo-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinoline-6-carboselenoic acid Se-phenyl ester

There total 3 articles about 9,10-dimethoxy-4-oxo-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinoline-6-carboselenoic acid Se-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 909281-73-8
9,10-dimethoxy-4-oxo-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinoline-6-carboxylic acid

: 1666-13-3
diphenyl diselenide

: 909281-74-9
9,10-dimethoxy-4-oxo-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinoline-6-carboselenoic acid Se-phenyl ester

Guidance literature:: With tributylphosphine; In dichloromethane; at 0 - 20 ℃; for 18h;
DOI:10.1016/j.tetlet.2006.06.035

Reference yield:

: 909281-72-7
9,10-dimethoxy-4-oxo-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinoline-6-carbaldehyde

: 909281-74-9
9,10-dimethoxy-4-oxo-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinoline-6-carboselenoic acid Se-phenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / NaClO₂; NaH₂PO₄; 1-methyl-1-cyclohexene / acetonitrile; H₂O; 2-methyl-propan-2-ol / 18 h / 0 - 20 °C

2: 76 percent / PBu₃ / CH₂Cl₂ / 18 h / 0 - 20 °C

With sodium chlorite; sodium dihydrogenphosphate; 1-methylcyclohex-1-ene; tributylphosphine; In dichloromethane; water; acetonitrile; tert-butyl alcohol;
DOI:10.1016/j.tetlet.2006.06.035

Reference yield:

: 459870-37-2
(6S,11bR)-6-Hydroxymethyl-9,10-dimethoxy-1,2,3,6,7,11b-hexahydro-pyrido[2,1-a]isoquinolin-4-one

: 909281-74-9
9,10-dimethoxy-4-oxo-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinoline-6-carboselenoic acid Se-phenyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / IBX / dimethylsulfoxide / 24 h / 20 °C

2: 86 percent / NaClO₂; NaH₂PO₄; 1-methyl-1-cyclohexene / acetonitrile; H₂O; 2-methyl-propan-2-ol / 18 h / 0 - 20 °C

3: 76 percent / PBu₃ / CH₂Cl₂ / 18 h / 0 - 20 °C

With sodium chlorite; sodium dihydrogenphosphate; 1-methylcyclohex-1-ene; tributylphosphine; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In dichloromethane; water; dimethyl sulfoxide; acetonitrile; tert-butyl alcohol;
DOI:10.1016/j.tetlet.2006.06.035