Trifluoro-methanesulfonic acid (E)-2-(1-benzenesulfonyl-1H-indol-3-yl)-2-cyano-vinyl ester

Base Information

Chemical Name:Trifluoro-methanesulfonic acid (E)-2-(1-benzenesulfonyl-1H-indol-3-yl)-2-cyano-vinyl ester
CAS No.:208644-80-8
Molecular Formula:C₁₈H₁₁F₃N₂O₅S₂
Molecular Weight:456.423
Hs Code.:

Synonyms:Trifluoro-methanesulfonic acid (E)-2-(1-benzenesulfonyl-1H-indol-3-yl)-2-cyano-vinyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Trifluoro-methanesulfonic acid (E)-2-(1-benzenesulfonyl-1H-indol-3-yl)-2-cyano-vinyl ester

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Technology Process of Trifluoro-methanesulfonic acid (E)-2-(1-benzenesulfonyl-1H-indol-3-yl)-2-cyano-vinyl ester

There total 2 articles about Trifluoro-methanesulfonic acid (E)-2-(1-benzenesulfonyl-1H-indol-3-yl)-2-cyano-vinyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 358-23-6
trifluoromethylsulfonic anhydride

: 208644-79-5
2-(1-benzenesulfonyl-1H-indol-3-yl)-3-hydroxyacrylonitrile

: 208644-80-8
Trifluoro-methanesulfonic acid (E)-2-(1-benzenesulfonyl-1H-indol-3-yl)-2-cyano-vinyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 5 ℃; for 0.0833333h;
DOI:10.3987/com-98-8109

Reference yield:

: 143703-45-1
2-[1-(benzenesulfonyl)indol-3-yl]acetonitrile

: 208644-80-8
Trifluoro-methanesulfonic acid (E)-2-(1-benzenesulfonyl-1H-indol-3-yl)-2-cyano-vinyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) LDA / 1.) THF, -50 deg C, 5 min, 2.) THF, -50 deg C to room t.

2: 66 percent / i-Pr₂NEt / CH₂Cl₂ / 0.08 h / 0 - 5 °C

With N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; In dichloromethane;
DOI:10.3987/com-98-8109

Reference yield: 77.0%

: 3-Tributylstannanyl-indole-1-carboxylic acid ethyl ester

: 208644-80-8
Trifluoro-methanesulfonic acid (E)-2-(1-benzenesulfonyl-1H-indol-3-yl)-2-cyano-vinyl ester

: 208644-81-9
3-[(E)-2-(1-Benzenesulfonyl-1H-indol-3-yl)-2-cyano-vinyl]-indole-1-carboxylic acid ethyl ester

Guidance literature:: With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium chloride; In tetrahydrofuran; for 1h; Heating;
DOI:10.3987/com-98-8109