Technology Process of 2-{2-(5-methylfuryl)}-4-(4-chloro-3,5-dimethylphenyl)-5-methylindene
There total 3 articles about 2-{2-(5-methylfuryl)}-4-(4-chloro-3,5-dimethylphenyl)-5-methylindene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: n-butyllithium / hexane; diethyl ether / 2 h / 0 - 20 °C
1.2: 16 h / -72 - 20 °C
2.1: N-Bromosuccinimide / water; dimethyl sulfoxide / 2 h / 0 - 20 °C
2.2: 1 h / Reflux
3.1: n-butyllithium / 1,2-dimethoxyethane; hexane / 2 h / -76 °C
3.2: 16 h / -30 - 20 °C
With
N-Bromosuccinimide; n-butyllithium;
In
1,2-dimethoxyethane; diethyl ether; hexane; water; dimethyl sulfoxide;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: N-Bromosuccinimide / water; dimethyl sulfoxide / 2 h / 0 - 20 °C
1.2: 1 h / Reflux
2.1: n-butyllithium / 1,2-dimethoxyethane; hexane / 2 h / -76 °C
2.2: 16 h / -30 - 20 °C
With
N-Bromosuccinimide; n-butyllithium;
In
1,2-dimethoxyethane; hexane; water; dimethyl sulfoxide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: hydrogenchloride; sodium nitrite / water / 0.33 h / 0 °C
1.2: 16 h / 20 - 70 °C
2.1: n-butyllithium / hexane; diethyl ether / 2 h / 0 - 20 °C
2.2: 16 h / -72 - 20 °C
3.1: N-Bromosuccinimide / water; dimethyl sulfoxide / 2 h / 0 - 20 °C
3.2: 1 h / Reflux
4.1: n-butyllithium / 1,2-dimethoxyethane; hexane / 2 h / -76 °C
4.2: 16 h / -30 - 20 °C
With
hydrogenchloride; N-Bromosuccinimide; n-butyllithium; sodium nitrite;
In
1,2-dimethoxyethane; diethyl ether; hexane; water; dimethyl sulfoxide;
