10.1055/s-2008-1032043
The research article details the synthesis of fluorinated cyclic hydrazine derivatives, which are significant due to their presence in biologically active compounds. The study employs ring-closing metathesis (RCM) as the key reaction to cyclize fluorinated and trifluoromethylated olefins into the desired hydrazines. The precursors for the RCM were prepared through a series of alkylation steps starting from diethyl azodicarboxylate or tert-butyl carbazate. The synthesized compounds were characterized using infrared (IR) spectroscopy, nuclear magnetic resonance (NMR) spectroscopy, and high-resolution mass spectrometry (HRMS). Crystallographic data for one of the synthesized hydrazines was also deposited, confirming its structure. The research provides a novel pathway to synthesize a potentially useful class of fluorinated cyclic hydrazines with potential pharmaceutical relevance.
10.1055/s-0029-1219906
The study reports the synthesis of 3-substituted L-fuco-azafagomines from D-lyxose, representing the first example of aza-C-glycosides with a biimino moiety. These compounds are potential selective inhibitors of a-L-fucosidases, enzymes involved in the biosynthetic processing of fucose-containing glycoconjugates and associated with various physiological and pathological events. The key step in the synthesis involves reductive hydrazination of a 1-deoxy-ketohexose with tert-butyl carbazate. The synthesized compounds, 3a and 3b, were tested for their inhibitory activities against twelve glycosidases, with 3a showing selective and competitive inhibition of a-L-fucosidase from bovine kidney. The study highlights the potential of these compounds as leads for developing new therapeutic agents targeting a-L-fucosidases.