2,3,4-[tris-O-(4-methoxyphenyl)methyl]-6-O-triphenylmethyl-5-deoxy-5-thio-α-D-glucopyranosyl trichloroacetimidate

Base Information

Chemical Name:2,3,4-[tris-O-(4-methoxyphenyl)methyl]-6-O-triphenylmethyl-5-deoxy-5-thio-α-D-glucopyranosyl trichloroacetimidate
CAS No.:565462-88-6
Molecular Formula:C₅₁H₅₀Cl₃NO₈S
Molecular Weight:943.385
Hs Code.:

Synonyms:2,3,4-[tris-O-(4-methoxyphenyl)methyl]-6-O-triphenylmethyl-5-deoxy-5-thio-α-D-glucopyranosyl trichloroacetimidate

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Chemical Property of 2,3,4-[tris-O-(4-methoxyphenyl)methyl]-6-O-triphenylmethyl-5-deoxy-5-thio-α-D-glucopyranosyl trichloroacetimidate

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Technology Process of 2,3,4-[tris-O-(4-methoxyphenyl)methyl]-6-O-triphenylmethyl-5-deoxy-5-thio-α-D-glucopyranosyl trichloroacetimidate

There total 13 articles about 2,3,4-[tris-O-(4-methoxyphenyl)methyl]-6-O-triphenylmethyl-5-deoxy-5-thio-α-D-glucopyranosyl trichloroacetimidate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 545-06-2
trichloroacetonitrile

: (3R,4S,5S,6R)-3,4,5-Tris-(4-methoxy-benzyloxy)-6-trityloxymethyl-tetrahydro-thiopyran-2-ol

: 565462-88-6
2,3,4-[tris-O-(4-methoxyphenyl)methyl]-6-O-triphenylmethyl-5-deoxy-5-thio-α-D-glucopyranosyl trichloroacetimidate

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 0 ℃;
DOI:10.1016/S0960-894X(03)00072-6

Reference yield:

: 137886-82-9
2,3,4,6-Tetra-O-acetyl-5-thio-α-D-glucopyranose

: 565462-88-6
2,3,4-[tris-O-(4-methoxyphenyl)methyl]-6-O-triphenylmethyl-5-deoxy-5-thio-α-D-glucopyranosyl trichloroacetimidate

Guidance literature:: Multi-step reaction with 6 steps

1: 95 percent / p-TsOH / CH₂Cl₂ / 1.5 h / 0 °C

2: 82 percent / NaOMe / methanol / 3.5 h / 20 °C

3: 80 percent / 4-(dimethylamino)pyridine; pyridine / 24 h / 20 °C

4: 56 percent / NaH / dimethylformamide / 20 °C

5: 16 percent / p-TsOH / ethanol / 7 h / 20 °C

6: 82 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene / CH₂Cl₂ / 0.67 h / 0 °C

With pyridine; dmap; sodium methylate; sodium hydride; toluene-4-sulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2005.05.028

Reference yield:

: 2746-25-0
p-Methoxybenzyl bromide

: 565462-88-6
2,3,4-[tris-O-(4-methoxyphenyl)methyl]-6-O-triphenylmethyl-5-deoxy-5-thio-α-D-glucopyranosyl trichloroacetimidate

Guidance literature:: Multi-step reaction with 3 steps

1: 62 percent / NaH / dimethylformamide; toluene / 20 °C

2: 92 percent / pyridinium 4-toluenesulfonate / ethanol; propan-1-ol / 2.5 h / 20 °C

3: 82 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene / CH₂Cl₂ / 0.67 h / 0 °C

With pyridinium p-toluenesulfonate; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In propan-1-ol; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmc.2005.05.028