(E)-N-(2,2-dimethylhepta-4,6-dien-1-yl)-4-methylbenzenesulfonamide

Base Information

• Chemical Name: (E)-N-(2,2-dimethylhepta-4,6-dien-1-yl)-4-methylbenzenesulfonamide
• CAS No.: 1351511-18-6
• Molecular Formula: C₁₆H₂₃NO₂S
• Molecular Weight: 293.43
• Mol file: 1351511-18-6.mol

Synonyms:(E)-N-(2,2-dimethylhepta-4,6-dien-1-yl)-4-methylbenzenesulfonamide

Chemical Property of (E)-N-(2,2-dimethylhepta-4,6-dien-1-yl)-4-methylbenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-N-(2,2-dimethylhepta-4,6-dien-1-yl)-4-methylbenzenesulfonamide

There total 5 articles about (E)-N-(2,2-dimethylhepta-4,6-dien-1-yl)-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

(E)-2,2-dimethylhepta-4,6-dien-1-amine (1351511-66-4) + p-toluenesulfonyl chloride (98-59-9) → (E)-N-(2,2-dimethylhepta-4,6-dien-1-yl)-4-methylbenzenesulfonamide (1351511-18-6)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 0 - 20 ℃; for 1h;

DOI:10.1021/ol300678r

Reference yield:

(E)-2,2-dimethylhepta-4,6-dienenitrile (1351511-64-2) + p-toluenesulfonyl chloride (98-59-9) → (E)-N-(2,2-dimethylhepta-4,6-dien-1-yl)-4-methylbenzenesulfonamide (1351511-18-6)

Guidance literature:

(E)-2,2-dimethylhepta-4,6-dienenitrile; With lithium aluminium tetrahydride; In diethyl ether; at 20 ℃; for 0.5h; Inert atmosphere;

p-toluenesulfonyl chloride; With triethylamine;

DOI:10.1039/c8cc04909b

Reference yield:

(E)-5-bromopenta-1,3-diene (52022-82-9) → (E)-N-(2,2-dimethylhepta-4,6-dien-1-yl)-4-methylbenzenesulfonamide (1351511-18-6)

Guidance literature:

Multi-step reaction with 3 steps

1: lithium diisopropyl amide / tetrahydrofuran / 3 h / -78 °C / Inert atmosphere

2: lithium aluminium tetrahydride / diethyl ether / 2.25 h / 0 - 20 °C / Inert atmosphere

3: triethylamine / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; dichloromethane;

DOI:10.1002/anie.201104076

upstream raw materials:

(E)-2,2-dimethylhepta-4,6-dienenitrile

(E)-2,2-dimethylhepta-4,6-dien-1-amine

p-toluenesulfonyl chloride

(E)-5-bromopenta-1,3-diene

Downstream raw materials:

(R)-2-allyl-4,4-dimethyl-1-tosylpyrrolidine

2-allyl-4,4-dimethyl-1-tosylpyrrolidine