methyl (2R)-2-(-)-α-methoxy-α-trifluoromethylphenylacetyloxytetracosanoate

Base Information

Chemical Name:methyl (2R)-2-(-)-α-methoxy-α-trifluoromethylphenylacetyloxytetracosanoate
CAS No.:112146-61-9
Molecular Formula:C₃₅H₅₇F₃O₅
Molecular Weight:614.83
Hs Code.:

Synonyms:methyl (2R)-2-(-)-α-methoxy-α-trifluoromethylphenylacetyloxytetracosanoate

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Chemical Property of methyl (2R)-2-(-)-α-methoxy-α-trifluoromethylphenylacetyloxytetracosanoate

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Technology Process of methyl (2R)-2-(-)-α-methoxy-α-trifluoromethylphenylacetyloxytetracosanoate

There total 6 articles about methyl (2R)-2-(-)-α-methoxy-α-trifluoromethylphenylacetyloxytetracosanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 2433-95-6,54563-86-9,54563-85-8
methyl (2R)-2-hydroxytetracosanoate

: 20445-33-4,39637-99-5
(R)-methoxytrifluoromethylphenylacetyl chloride

: 112146-61-9
methyl (2R)-2-(-)-α-methoxy-α-trifluoromethylphenylacetyloxytetracosanoate

Guidance literature:: In pyridine; at 20 ℃; for 16h;
DOI:10.1016/0008-6215(87)80219-7

Reference yield:

: 112-85-6
n-docosanoic acid

: 112146-61-9
methyl (2R)-2-(-)-α-methoxy-α-trifluoromethylphenylacetyloxytetracosanoate

Guidance literature:: Multi-step reaction with 5 steps

1: 14 percent / NaOEt / ethanol / anodic coupling

2: 94 percent / MeONa / tetrahydrofuran; methanol / 16 h / 5 °C

3: 92 percent / Ph₃P, diethyl azodicarboxylate / tetrahydrofuran / 1 h / 20 °C

4: 74 percent / MeONa / tetrahydrofuran; methanol / 16 h / 5 °C

5: 71 percent / pyridine / 16 h / 20 °C

With sodium methylate; sodium ethanolate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; pyridine; methanol; ethanol;
DOI:10.1016/0008-6215(87)80219-7

Reference yield:

: 112146-54-0
ethyl (2S)-2-acetoxytetracosanoate

: 112146-61-9
methyl (2R)-2-(-)-α-methoxy-α-trifluoromethylphenylacetyloxytetracosanoate

Guidance literature:: Multi-step reaction with 4 steps

1: 94 percent / MeONa / tetrahydrofuran; methanol / 16 h / 5 °C

2: 92 percent / Ph₃P, diethyl azodicarboxylate / tetrahydrofuran / 1 h / 20 °C

3: 74 percent / MeONa / tetrahydrofuran; methanol / 16 h / 5 °C

4: 71 percent / pyridine / 16 h / 20 °C

With sodium methylate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; pyridine; methanol;
DOI:10.1016/0008-6215(87)80219-7