Carbonic acid (2R,3R)-5-(2-dimethylamino-ethyl)-8-fluoro-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester ethyl ester

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Chemical Name:Carbonic acid (2R,3R)-5-(2-dimethylamino-ethyl)-8-fluoro-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester ethyl ester
CAS No.:130884-78-5
Molecular Formula:C₂₃H₂₇FN₂O₅S
Molecular Weight:462.542
Hs Code.:

Synonyms:Carbonic acid (2R,3R)-5-(2-dimethylamino-ethyl)-8-fluoro-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester ethyl ester

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Chemical Property of Carbonic acid (2R,3R)-5-(2-dimethylamino-ethyl)-8-fluoro-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester ethyl ester

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Technology Process of Carbonic acid (2R,3R)-5-(2-dimethylamino-ethyl)-8-fluoro-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester ethyl ester

There total 3 articles about Carbonic acid (2R,3R)-5-(2-dimethylamino-ethyl)-8-fluoro-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 348-40-3
2-amino-6-fluoro-1,3-benzothiazole

: 130884-78-5
Carbonic acid (2R,3R)-5-(2-dimethylamino-ethyl)-8-fluoro-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 75.5 percent / aq. NaOH / Heating

2: 15.4 percent / 16 h / 160 °C

3: aq. K₂CO₃ / acetone / 17 h / Heating

4: pyridine / 3 h / Ambient temperature

With pyridine; sodium hydroxide; potassium carbonate; In acetone;
DOI:10.1021/jm00106a032

Reference yield:

: 100492-87-3
(2S,3S)-8-Fluoro-3-hydroxy-2-(4-methoxy-phenyl)-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one

: 130884-78-5
Carbonic acid (2R,3R)-5-(2-dimethylamino-ethyl)-8-fluoro-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: aq. K₂CO₃ / acetone / 17 h / Heating

2: pyridine / 3 h / Ambient temperature

With pyridine; potassium carbonate; In acetone;
DOI:10.1021/jm00106a032