1-(2-(4'-fluoro-[1,1'-biphenyl]-4-yl)-1,6-naphthyridin-4-yl)imidazolidin-2-one

Base Information

Chemical Name:1-(2-(4'-fluoro-[1,1'-biphenyl]-4-yl)-1,6-naphthyridin-4-yl)imidazolidin-2-one
CAS No.:1620951-98-5
Molecular Formula:C₂₃H₁₇FN₄O
Molecular Weight:384.413
Hs Code.:

Synonyms:1-(2-(4'-fluoro-[1,1'-biphenyl]-4-yl)-1,6-naphthyridin-4-yl)imidazolidin-2-one

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Chemical Property of 1-(2-(4'-fluoro-[1,1'-biphenyl]-4-yl)-1,6-naphthyridin-4-yl)imidazolidin-2-one

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Technology Process of 1-(2-(4'-fluoro-[1,1'-biphenyl]-4-yl)-1,6-naphthyridin-4-yl)imidazolidin-2-one

There total 12 articles about 1-(2-(4'-fluoro-[1,1'-biphenyl]-4-yl)-1,6-naphthyridin-4-yl)imidazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.0%

: 1620955-64-7
C₂₀H₁₂BrFN₂

: 82933-19-5
tert-Butyloxycarbonyl-imidazolidin-2-one

: 1620951-98-5
1-(2-(4'-fluoro-[1,1'-biphenyl]-4-yl)-1,6-naphthyridin-4-yl)imidazolidin-2-one

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; In toluene; for 20h; Inert atmosphere; Reflux;

Reference yield:

: 98400-69-2
N-(4-pyridyl) t-butyl carbamate

: 1620951-98-5
1-(2-(4'-fluoro-[1,1'-biphenyl]-4-yl)-1,6-naphthyridin-4-yl)imidazolidin-2-one

Guidance literature:: Multi-step reaction with 9 steps

1.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 - 0 °C / Inert atmosphere

1.2: 2 h / -78 - 20 °C

2.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 16 h / 0 - 20 °C / Inert atmosphere

3.1: tetrahydrofuran / 1 h / -78 - 20 °C

4.1: trifluoroacetic acid / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere

5.1: triethylamine / dichloromethane / 2.25 h / -20 - 20 °C / Inert atmosphere

6.1: sodium hydroxide / 1,4-dioxane / 2 h / 100 °C / Inert atmosphere; Sealed tube

7.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; water / 12 h / Inert atmosphere; Reflux

8.1: phosphorus(V) oxybromide / 2 h / 110 °C / Inert atmosphere

9.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate / toluene / 20 h / Inert atmosphere; Reflux

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; potassium carbonate; benzotriazol-1-ol; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; sodium t-butanolate; phosphorus(V) oxybromide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 244780-32-3
[3-(methoxy-methyl-carbamoyl)-pyridin-4-yl]-carbamic acid tert-butyl ester

: 1620951-98-5
1-(2-(4'-fluoro-[1,1'-biphenyl]-4-yl)-1,6-naphthyridin-4-yl)imidazolidin-2-one

Guidance literature:: Multi-step reaction with 7 steps

1: tetrahydrofuran / 1 h / -78 - 20 °C

2: trifluoroacetic acid / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere

3: triethylamine / dichloromethane / 2.25 h / -20 - 20 °C / Inert atmosphere

4: sodium hydroxide / 1,4-dioxane / 2 h / 100 °C / Inert atmosphere; Sealed tube

5: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; water / 12 h / Inert atmosphere; Reflux

6: phosphorus(V) oxybromide / 2 h / 110 °C / Inert atmosphere

7: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate / toluene / 20 h / Inert atmosphere; Reflux

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine; trifluoroacetic acid; sodium hydroxide; sodium t-butanolate; phosphorus(V) oxybromide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; toluene;