(+)-(2R)-2-acetyl-5-benzyloxy-2-(t-butyldimethylsilyloxy)-8-methoxy-1,2,3,4-tetrahydronaphthalene

Base Information

Chemical Name:(+)-(2R)-2-acetyl-5-benzyloxy-2-(t-butyldimethylsilyloxy)-8-methoxy-1,2,3,4-tetrahydronaphthalene
CAS No.:90773-77-6
Molecular Formula:C₂₆H₃₆O₄Si
Molecular Weight:440.655
Hs Code.:

Synonyms:(+)-(2R)-2-acetyl-5-benzyloxy-2-(t-butyldimethylsilyloxy)-8-methoxy-1,2,3,4-tetrahydronaphthalene

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Chemical Property of (+)-(2R)-2-acetyl-5-benzyloxy-2-(t-butyldimethylsilyloxy)-8-methoxy-1,2,3,4-tetrahydronaphthalene

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Technology Process of (+)-(2R)-2-acetyl-5-benzyloxy-2-(t-butyldimethylsilyloxy)-8-methoxy-1,2,3,4-tetrahydronaphthalene

There total 5 articles about (+)-(2R)-2-acetyl-5-benzyloxy-2-(t-butyldimethylsilyloxy)-8-methoxy-1,2,3,4-tetrahydronaphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 69739-34-0
t-butyldimethylsiyl triflate

: 90821-32-2
(-)-(2R)-2-acetyl-5-benzyloxy-8-methoxy-1,2,3,4-tetrahydronaphthalen-1-ol

: 90773-77-6
(+)-(2R)-2-acetyl-5-benzyloxy-2-(t-butyldimethylsilyloxy)-8-methoxy-1,2,3,4-tetrahydronaphthalene

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; for 2h;
DOI:10.1071/CH9850179

Reference yield:

: 90744-26-6
(-)-(2R,1'S)-5-benzyloxy-2-(1'-hydroxyethyl)-8-methoxy-1,2,3,4-tetrahydronaphthalen-2-ol

: 90773-77-6
(+)-(2R)-2-acetyl-5-benzyloxy-2-(t-butyldimethylsilyloxy)-8-methoxy-1,2,3,4-tetrahydronaphthalene

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / Fetizon's reagent / benzene / 1 h / Heating

2: 93 percent / 2,6-dimethylpyridine / CH₂Cl₂ / 2 h

With 2,6-dimethylpyridine; silver carbonate; In dichloromethane; benzene;
DOI:10.1071/CH9850179

Reference yield:

: 89144-50-3
3-acetyl-8-benzyloxy-5-methoxy-1,2-dihydronaphthalene

: 90773-77-6
(+)-(2R)-2-acetyl-5-benzyloxy-2-(t-butyldimethylsilyloxy)-8-methoxy-1,2,3,4-tetrahydronaphthalene

Guidance literature:: Multi-step reaction with 5 steps

1: 77 percent / (-)-N-methylephedrine, N-ethylaniline, LiAlH₄ / diethyl ether / 1 h / -78 °C

2: vanadium(IV) bis(pentane-2,4-dionate) oxide, t-butyl hydroperoxide / benzene / 1.5 h

3: 77 percent / LiAlH₄ / benzene; diethyl ether / Ambient temperature

4: 80 percent / Fetizon's reagent / benzene / 1 h / Heating

5: 93 percent / 2,6-dimethylpyridine / CH₂Cl₂ / 2 h

With 2,6-dimethylpyridine; tert.-butylhydroperoxide; lithium aluminium tetrahydride; bis(acetylacetonate)oxovanadium; (-)-N-methylephedrine; N-ethyl-N-phenylamine; silver carbonate; In diethyl ether; dichloromethane; benzene;
DOI:10.1071/CH9850179