tert-butyl (S)-(1-hydroxy-3-(4-(trifluoromethyl)phenyl)propan-2-yl)carbamate

Base Information

Chemical Name:tert-butyl (S)-(1-hydroxy-3-(4-(trifluoromethyl)phenyl)propan-2-yl)carbamate
CAS No.:944470-71-7
Molecular Formula:C₁₅H₂₀F₃NO₃
Molecular Weight:319.324
Hs Code.:

Synonyms:tert-butyl (S)-(1-hydroxy-3-(4-(trifluoromethyl)phenyl)propan-2-yl)carbamate

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Chemical Property of tert-butyl (S)-(1-hydroxy-3-(4-(trifluoromethyl)phenyl)propan-2-yl)carbamate

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Technology Process of tert-butyl (S)-(1-hydroxy-3-(4-(trifluoromethyl)phenyl)propan-2-yl)carbamate

There total 2 articles about tert-butyl (S)-(1-hydroxy-3-(4-(trifluoromethyl)phenyl)propan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 82317-83-7,114873-07-3
N-tert-butoxycarbonyl-L-4-trifluoromethylphenylalanine

: 944470-71-7
tert-butyl (S)-(1-hydroxy-3-(4-(trifluoromethyl)phenyl)propan-2-yl)carbamate

Guidance literature:: N-tert-butoxycarbonyl-L-4-trifluoromethylphenylalanine; With 4-methyl-morpholine; chloroformic acid ethyl ester; In tetrahydrofuran; at -10 ℃; for 0.75h;

With sodium tetrahydroborate; In tetrahydrofuran;

With hydrogenchloride; methanol; water; more than 3 stages;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 153181-07-8
(S)-2-amino-3-(4-(trifluoromethyl)phenyl)propan-1-ol

: 944470-71-7
tert-butyl (S)-(1-hydroxy-3-(4-(trifluoromethyl)phenyl)propan-2-yl)carbamate

Guidance literature:: With sodium hydrogencarbonate; In water; acetone; at 20 ℃;

Reference yield: 85.0%

: 944470-71-7
tert-butyl (S)-(1-hydroxy-3-(4-(trifluoromethyl)phenyl)propan-2-yl)carbamate

: 1104069-86-4
(R,S)-tert-butyl-(S)-4-(4-trifluoromethylbenzyl)-1,2,3-oxathiazolidine-3-carboxylate-2-oxide

Guidance literature:: tert-butyl (S)-(1-hydroxy-3-(4-(trifluoromethyl)phenyl)propan-2-yl)carbamate; With thionyl chloride; In dichloromethane; at -50 - -40 ℃;

With pyridine; In dichloromethane; at -50 ℃; for 3h;