Pharmakon1600-01505709

Base Information

• Chemical Name: Pharmakon1600-01505709
• CAS No.: 50700-72-6
• Molecular Formula: Br*C₃₄H₅₇N₂O₄
• Molecular Weight: 637.742
• Hs Code.: 2933399090
• NSC Number: 759184
• Mol file: 50700-72-6.mol

Synonyms:Pharmakon1600-01505709;NSC759184;CCG-213525;SR-05000001948;SR-05000001948-1

Chemical Property of Pharmakon1600-01505709

Chemical Property:

• Appearance/Colour: white powder
• Melting Point: 227-229 °C
• PSA: 55.84000
• Density: ==
• LogP: 2.86660
• Storage Temp.: -20°C Freezer
• Solubility.: Slightly soluble in water, freely soluble in methylene chloride, sparingly soluble in acetonitrile and in anhydrous ethanol.
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 6
• Exact Mass: 636.35017
• Heavy Atom Count: 41
• Complexity: 958

Purity/Quality:

98%min ^*data from raw suppliers

Vecuronium Bromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)OC1CC2CCC3C(C2(CC1N4CCCCC4)C)CCC5(C3CC(C5OC(=O)C)[N+]6(CCCCC6)C)C.[Br-]
• Isomeric SMILES: CC(=O)O[C@H]1CC2CCC3C([C@]2(C[C@@H]1N4CCCCC4)C)CC[C@]5(C3C[C@@H]([C@@H]5OC(=O)C)[N+]6(CCCCC6)C)C.[Br-]
• Description: Vecuronium bromide (Brand name: Norcuron) is a drug which can be supplied to general anesthesia to keep skeletal muscle relaxation during the surgery or mechanical ventilation. It can also be used to help with endotracheal intubation. It has rapid onset (within 4 minutes) and has its effect last for 4 hour. Its mechanism of action is through competitively binding to the nicotinic cholinergic receptors, further antagonizing the opportunity for acetylcholine from binding to the nicotinic receptor at the postjunctional membrane of the myoneural junction. This process prevents the depolarization and the release of calcium ions, stopping muscle contraction and help muscle relaxation. Vecuronium, 1-[(2β,3α,5α,16β,17β,)-3,17-bis(acetyloxy)-2-(1-piperidinyl) androstan-16-yl]-1-methylpiperidinium bromide (15.1.9), differs from panuronium only in the extent of alkylation. Only the piperidine substituent on C16 of the steroid skeleton is transformed into a quaternary salt. Vecuronium is a non-depolarizing muscle relaxant derived from the aminosteroid pancuronium and used adjunctively to general anesthesia. It competitively blocks cholinergic receptors at the motor end plate of the neuromuscular junction, inducing temporary paralysis. In humans, it has been shown to reduce muscle twitch tension with an ED50 value of 0.15 mg/kg for a duration of 27 minutes without inducing cardiovascular effects.
• Uses: alcohol antagonist An aminosteroid, competitive neuromuscular blocker agent.
• Biological Functions: Vecuronium bromide (Norcuron) is chemically identical to pancuronium except for a tertiary amine in place of a quaternary nitrogen. However, some of the drug will exist as the bisquaternary compound, depending on body pH. Vecuronium has a moderate onset of action (2.4 minutes) and a duration of effect of about 50 minutes. Like pancuronium, it does not block ganglia or vagal neuroeffector junctions, does not release histamine, and is eliminated by urinary excretion.
• Clinical Use: Vecuronium Bromide is usedmainly to produce skeletal muscle relaxation during surgeryand to assist in controlled respiration after general anesthesiahas been induced.
• Drug interactions: Potentially hazardous interactions with other drugs Anaesthetics: enhanced muscle relaxant effect. Anti-arrhythmics: procainamide enhances muscle relaxant effect. Antibacterials: effect enhanced by aminoglycosides, clindamycin, polymyxins and piperacillin. Antiepileptics: muscle relaxant effects antagonised by carbamazepine; effects reduced by long-term use of fosphenytoin and phenytoin but might be increased by acute use. Botulinum toxin: neuromuscular block enhanced (risk of toxicity).

Technology Process of Pharmakon1600-01505709

There total 1 articles about Pharmakon1600-01505709 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ vecuronium bromide (50700-72-6,119302-64-6)

Guidance literature:

entspr. Piperidinverb., CH3Br in Aether;

DOI:10.1021/jm00268a011