1-Benzyl 2-(tert-butyl) 1,2-diazepane-1,2-dicarboxylate

Base Information

• Chemical Name: 1-Benzyl 2-(tert-butyl) 1,2-diazepane-1,2-dicarboxylate
• CAS No.: 443295-19-0
• Molecular Formula: C₁₈H₂₆N₂O₄
• Molecular Weight: 334.415
• Mol file: 443295-19-0.mol

Synonyms:benzyl 2-(tert-butoxycarbonyl)hexahydro-1,2-diazepine-1-carboxylate

Chemical Property of 1-Benzyl 2-(tert-butyl) 1,2-diazepane-1,2-dicarboxylate

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

1-BENZYL 2-(TERT-BUTYL) 1,2-DIAZEPANE-1,2-DICARBOXYLATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Benzyl 2-(tert-butyl) 1,2-diazepane-1,2-dicarboxylate

There total 1 articles about 1-Benzyl 2-(tert-butyl) 1,2-diazepane-1,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

1,5-dibromo-pentane (111-24-0) + 1-tert-butoxycarbonyl-2-carbobenzyloxyhydrazine (57699-88-4) → benzyl 2-(tert-butoxycarbonyl)hexahydro-1,2-diazepine-1-carboxylate (443295-19-0)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/S0968-0896(01)00353-4

Reference yield: 96.0%

benzyl 2-(tert-butoxycarbonyl)hexahydro-1,2-diazepine-1-carboxylate (443295-19-0) → tert-butyl hexahydro-1,2-diazepine-1-carboxylate (443295-32-7)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 3h; under 760 Torr;

DOI:10.1016/S0968-0896(01)00353-4

Reference yield:

benzyl 2-(tert-butoxycarbonyl)hexahydro-1,2-diazepine-1-carboxylate (443295-19-0) → 1-(4-chlorobenzoyl)hexahydro-1,2-diazepine (443295-33-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 96 percent / H₂ / Pd/C / methanol / 3 h / 20 °C / 760 Torr

2: 76 percent / Et₃N / CH₂Cl₂ / 20 °C

3: 99 percent / TFA / CH₂Cl₂ / 0.5 h / 0 °C

With hydrogen; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In methanol; dichloromethane;

DOI:10.1016/S0968-0896(01)00353-4

upstream raw materials:

1,5-dibromo-pentane

1-tert-butoxycarbonyl-2-carbobenzyloxyhydrazine

Downstream raw materials:

tert-butyl hexahydro-1,2-diazepine-1-carboxylate

1-(4-chlorobenzoyl)hexahydro-1,2-diazepine

tert-butyl 2-(4-chlorobenzoyl)hexahydro-1,2-diazepine-1-carboxylate