(E)-7-(2-Phenylsulfanyl-acetyl)-6,7,8,9-tetrahydro-5H-7,12-diaza-cyclonona[a]indene-11,12-dicarboxylic acid dimethyl ester

Base Information

• Chemical Name: (E)-7-(2-Phenylsulfanyl-acetyl)-6,7,8,9-tetrahydro-5H-7,12-diaza-cyclonona[a]indene-11,12-dicarboxylic acid dimethyl ester
• CAS No.: 141321-21-3
• Molecular Formula: C₂₆H₂₆N₂O₅S
• Molecular Weight: 478.569
• Mol file: 141321-21-3.mol

Synonyms:(E)-7-(2-Phenylsulfanyl-acetyl)-6,7,8,9-tetrahydro-5H-7,12-diaza-cyclonona[a]indene-11,12-dicarboxylic acid dimethyl ester

Chemical Property of (E)-7-(2-Phenylsulfanyl-acetyl)-6,7,8,9-tetrahydro-5H-7,12-diaza-cyclonona[a]indene-11,12-dicarboxylic acid dimethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-7-(2-Phenylsulfanyl-acetyl)-6,7,8,9-tetrahydro-5H-7,12-diaza-cyclonona[a]indene-11,12-dicarboxylic acid dimethyl ester

There total 3 articles about (E)-7-(2-Phenylsulfanyl-acetyl)-6,7,8,9-tetrahydro-5H-7,12-diaza-cyclonona[a]indene-11,12-dicarboxylic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

(phenylthio)acetic acid (103-04-8) + (E)-6,7,8,9-Tetrahydro-5H-7,12-diaza-cyclonona[a]indene-11,12-dicarboxylic acid dimethyl ester (141321-20-2) → (E)-7-(2-Phenylsulfanyl-acetyl)-6,7,8,9-tetrahydro-5H-7,12-diaza-cyclonona[a]indene-11,12-dicarboxylic acid dimethyl ester (141321-21-3)

Guidance literature:

With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; In dichloromethane;

DOI:10.1021/ja00037a058

Reference yield:

(E)-5,8,9,12-Tetrahydro-6H-7,12-diaza-cyclonona[a]indene-7,11-dicarboxylic acid 11-methyl ester 7-(2,2,2-trichloro-ethyl) ester (141321-18-8) → (E)-7-(2-Phenylsulfanyl-acetyl)-6,7,8,9-tetrahydro-5H-7,12-diaza-cyclonona[a]indene-11,12-dicarboxylic acid dimethyl ester (141321-21-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 90 percent / aq. NaOH, PTC / CH₂Cl₂

2: 90 percent / Zn, AcOH / tetrahydrofuran

3: 69 percent / BOPCl, Et₃N / CH₂Cl₂

With sodium hydroxide; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; acetic acid; triethylamine; zinc; In tetrahydrofuran; dichloromethane;

DOI:10.1021/ja00037a058

Reference yield:

(E)-5,6,8,9-Tetrahydro-7,12-diaza-cyclonona[a]indene-7,11,12-tricarboxylic acid 11,12-dimethyl ester 7-(2,2,2-trichloro-ethyl) ester (141321-19-9) → (E)-7-(2-Phenylsulfanyl-acetyl)-6,7,8,9-tetrahydro-5H-7,12-diaza-cyclonona[a]indene-11,12-dicarboxylic acid dimethyl ester (141321-21-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / Zn, AcOH / tetrahydrofuran

2: 69 percent / BOPCl, Et₃N / CH₂Cl₂

With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; acetic acid; triethylamine; zinc; In tetrahydrofuran; dichloromethane;

DOI:10.1021/ja00037a058

upstream raw materials:

(phenylthio)acetic acid

(E)-6,7,8,9-Tetrahydro-5H-7,12-diaza-cyclonona[a]indene-11,12-dicarboxylic acid dimethyl ester

(E)-5,8,9,12-Tetrahydro-6H-7,12-diaza-cyclonona[a]indene-7,11-dicarboxylic acid 11-methyl ester 7-(2,2,2-trichloro-ethyl) ester

(E)-5,6,8,9-Tetrahydro-7,12-diaza-cyclonona[a]indene-7,11,12-tricarboxylic acid 11,12-dimethyl ester 7-(2,2,2-trichloro-ethyl) ester

Downstream raw materials:

(E)-7-(2-Benzenesulfinyl-acetyl)-6,7,8,9-tetrahydro-5H-7,12-diaza-cyclonona[a]indene-11,12-dicarboxylic acid dimethyl ester