1-(4-(2-(2-(2,3-difluorophenylacetyl)hydrazinocarbonyl)pyridine-4-yloxy)phenyl)-3-(4-chloro-3-trifluoromethylphenyl)urea

Base Information

Chemical Name:1-(4-(2-(2-(2,3-difluorophenylacetyl)hydrazinocarbonyl)pyridine-4-yloxy)phenyl)-3-(4-chloro-3-trifluoromethylphenyl)urea
CAS No.:1610930-14-7
Molecular Formula:C₂₈H₁₉ClF₅N₅O₄
Molecular Weight:619.935
Hs Code.:

Synonyms:1-(4-(2-(2-(2,3-difluorophenylacetyl)hydrazinocarbonyl)pyridine-4-yloxy)phenyl)-3-(4-chloro-3-trifluoromethylphenyl)urea

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Chemical Property of 1-(4-(2-(2-(2,3-difluorophenylacetyl)hydrazinocarbonyl)pyridine-4-yloxy)phenyl)-3-(4-chloro-3-trifluoromethylphenyl)urea

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 1-(4-(2-(2-(2,3-difluorophenylacetyl)hydrazinocarbonyl)pyridine-4-yloxy)phenyl)-3-(4-chloro-3-trifluoromethylphenyl)urea

There total 5 articles about 1-(4-(2-(2-(2,3-difluorophenylacetyl)hydrazinocarbonyl)pyridine-4-yloxy)phenyl)-3-(4-chloro-3-trifluoromethylphenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1‐(4‐chloro‐3‐(trifluoromethyl)phenyl)‐3‐(4‐((2‐(hydrazinecarbonyl)pyridin‐4‐yl)oxy)phenyl)urea

: 145689-41-4
2-(2,3-difluorophenyl)acetic acid

: 1610930-14-7
1-(4-(2-(2-(2,3-difluorophenylacetyl)hydrazinocarbonyl)pyridine-4-yloxy)phenyl)-3-(4-chloro-3-trifluoromethylphenyl)urea

Guidance literature:: With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 12h;
DOI:10.1016/j.cclet.2014.03.020

Reference yield:

: 24484-93-3
4-Chloro-pyridine-2-carboxylic acid methyl ester

: 1610930-14-7
1-(4-(2-(2-(2,3-difluorophenylacetyl)hydrazinocarbonyl)pyridine-4-yloxy)phenyl)-3-(4-chloro-3-trifluoromethylphenyl)urea

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium tert-butylate / N,N-dimethyl-formamide / 2 h / 20 °C

1.2: 8 h / 80 °C / Inert atmosphere

2.1: dichloromethane / 0 - 20 °C / Inert atmosphere

3.1: hydrazine hydrate / deuteromethanol / 10 h / Reflux

4.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 12 h / 20 °C

With potassium tert-butylate; hydrazine hydrate; triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; deuteromethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.cclet.2014.03.020

Reference yield:

: 123-30-8
4-amino-phenol

: 1610930-14-7
1-(4-(2-(2-(2,3-difluorophenylacetyl)hydrazinocarbonyl)pyridine-4-yloxy)phenyl)-3-(4-chloro-3-trifluoromethylphenyl)urea

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium tert-butylate / N,N-dimethyl-formamide / 2 h / 20 °C

1.2: 8 h / 80 °C / Inert atmosphere

2.1: dichloromethane / 0 - 20 °C / Inert atmosphere

3.1: hydrazine hydrate / deuteromethanol / 10 h / Reflux

4.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 12 h / 20 °C

With potassium tert-butylate; hydrazine hydrate; triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; deuteromethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.cclet.2014.03.020