Doxazosin

Base Information Edit

Chemical Name:Doxazosin
CAS No.:74191-85-8
Deprecated CAS:137888-77-8
Molecular Formula:C23H25N5O5
Molecular Weight:451.482
Hs Code.:
European Community (EC) Number:616-059-6
UNII:NW1291F1W8
DSSTox Substance ID:DTXSID7022964
Nikkaji Number:J21.371C
Wikipedia:Doxazosin
Wikidata:Q419939
NCI Thesaurus Code:C61737
RXCUI:49276
Pharos Ligand ID:UHH3DL48PFUU
Metabolomics Workbench ID:42921
ChEMBL ID:CHEMBL707
Mol file:74191-85-8.mol

Synonyms:1 (4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-((2,3-dihydro-1,4-benzodioxin-2-yl)carbonyl)piperazine;Alfamedin;Apo Doxazosin;Apo-Doxazosin;Cardular;Cardura;Carduran;Carduran Neo;ct, doxazosin von;Diblocin;Doxa Puren;Doxa-Puren;Doxacor;Doxagamma;Doxamax;Doxatensa;DoxaUro;Doxazomerck;Doxazosin;Doxazosin AL;Doxazosin Apogepha;Doxazosin AZU;Doxazosin beta;Doxazosin findusFit;Doxazosin Heumann;Doxazosin Klast;Doxazosin Mesylate;Doxazosin Monohydrochloride;Doxazosin ratiopharm;Doxazosin Stada;doxazosin von ct;Doxazosin Wolff;Doxazosin-ratiopharm;Doxazosin-Wolff;Doxazosina Alter;Doxazosina Cinfa;Doxazosina Combino Pharm;Doxazosina Geminis;Doxazosina Normon;Doxazosina Pharmagenus;Doxazosina Ratiopharm;Doxazosina Ur;Gen Doxazosin;Gen-Doxazosin;Jutalar;Mesylate, Doxazosin;Monohydrochloride, Doxazosin;MTW Doxazosin;MTW-Doxazosin;Neo, Carduran;Novo Doxazosin;Novo-Doxazosin;Progandol Neo;ratio Doxazosin;ratio-Doxazosin;Ratiopharm, Doxazosina;UK 33274;UK-33274;UK33274;Uriduct;von ct, doxazosin;Zoxan

Suppliers and Price of Doxazosin

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Medical Isotopes, Inc.
Doxazosin-d8
5 mg
$ 1600.00

Crysdot
Doxazosin 98+%
1g
$ 292.00

AvaChem
Doxazosin
1g
$ 115.00

AvaChem
Doxazosin
100mg
$ 39.00

AvaChem
Doxazosin
5g
$ 390.00

ApexBio Technology
Doxazosin
100mg
$ 142.00

ApexBio Technology
Doxazosin
500mg
$ 434.00

American Custom Chemicals Corporation
DOXAZOSIN 95.00%
2.5G
$ 983.88

American Custom Chemicals Corporation
DOXAZOSIN 95.00%
1G
$ 721.57

American Custom Chemicals Corporation
DOXAZOSIN 95.00%
100MG
$ 205.80

Total 75 raw suppliers

Chemical Property of Doxazosin Edit

Chemical Property:

Vapor Pressure:1.83E-20mmHg at 25°C
Melting Point:289-290 °C
Boiling Point:718 °C at 760 mmHg
PKA:6.52±0.50(Predicted)
Flash Point:388 °C
PSA：175.02000
Density:1.371 g/cm³
LogP:2.88670
XLogP3:2.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:4
Exact Mass:451.18556891
Heavy Atom Count:33
Complexity:678

Purity/Quality:

99%MIN ^*data from raw suppliers

Doxazosin-d8 ^*data from reagent suppliers

Safty Information:

Pictogram(s): T,Xi
Hazard Codes:T,Xi

MSDS Files:: SDS file from LookChem

Useful:

Drug Classes:Antihypertensive Agents
Canonical SMILES:COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4COC5=CC=CC=C5O4)N)OC
Recent ClinicalTrials:Alpha-1 Blockade for Alcohol Use Disorder (AUD)
Recent EU Clinical Trials:Treating Nightmares in Posttraumatic Stress Disorder with the α-adrenergic Agents Clonidine and Doxazosin: A Randomized-Controlled Feasibility Study (ClonDoTrial)
Recent NIPH Clinical Trials:Japan Morning Surge -1 study
Description Doxazosin mesylate is a selective alpha, blocker indicated for the treatment of hypertension, reportedly of special benefit as a first-line agent in the most hypertonic patient population. Another advantage of doxazosin is its favorable effect on blood lipids; it significantly increases the HDL/total cholesterol ratio and decreases the total cholesterol as well as triglycerides levels.
Uses ACIPHEX therapeutic Erosive or Ulcerative Gastroesophageal Reflux Disease
Clinical Use Alpha-adrenoceptor blocker:HypertensionBenign prostatic hyperplasia (BPH)
Drug interactions Potentially hazardous interactions with other drugsAntidepressants: enhanced hypotensive effect with MAOIs.Avanafil, vardenafil, sildenafil and tadalafil: enhanced hypotensive effect, avoid with tadalafil, start the others at the lowest possible dose.Beta-blockers: enhanced hypotensive effect; increased risk of first dose hypotensive effect.Calcium-channel blockers: enhanced hypotensive effect, increased risk of first dose hypotensive effect.Diuretics: enhanced hypotensive effect, increased risk of first dose hypotensive effect.Moxisylyte: possibly severe postural hypotension when used in combination.

Technology Process of Doxazosin

There total 11 articles about Doxazosin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.2%