4'-chloro-2-methyl-biphenyl-4-sulfonic acid (2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)-amide

Base Information

• Chemical Name: 4'-chloro-2-methyl-biphenyl-4-sulfonic acid (2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)-amide
• CAS No.: 783302-10-3
• Molecular Formula: C₂₃H₂₃ClN₂O₂S
• Molecular Weight: 426.967
• Mol file: 783302-10-3.mol

Synonyms:4'-chloro-2-methyl-biphenyl-4-sulfonic acid (2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)-amide

Chemical Property of 4'-chloro-2-methyl-biphenyl-4-sulfonic acid (2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4'-chloro-2-methyl-biphenyl-4-sulfonic acid (2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)-amide

There total 3 articles about 4'-chloro-2-methyl-biphenyl-4-sulfonic acid (2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

7-(4'-chloro-2-methyl-biphenyl-4-sulfonylamino)-1,2,4,5-tetrahydro-benzo[d]azepine-3-carboxylic acid tert-butyl ester (956116-94-2) → 4'-chloro-2-methyl-biphenyl-4-sulfonic acid (2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)-amide (783302-10-3)

Guidance literature:

With hydrogenchloride; In ethanol; at 20 ℃; for 2h;

DOI:10.1016/j.bmcl.2006.10.036

Reference yield:

4'-chloro-2-methyl-biphenyl-4-sulfonyl chloride → 4'-chloro-2-methyl-biphenyl-4-sulfonic acid (2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)-amide (783302-10-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / pyridine / CH₂Cl₂ / 12 h / 20 °C

2: 78 percent / HCl / ethanol / 2 h / 20 °C

With pyridine; hydrogenchloride; In ethanol; dichloromethane;

DOI:10.1016/j.bmcl.2006.10.036

Reference yield:

7-amino-1,2,4,5-tetrahydro-benzo[d]azepine-3-carboxylic acid tert-butyl ester (118454-24-3) → 4'-chloro-2-methyl-biphenyl-4-sulfonic acid (2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)-amide (783302-10-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / pyridine / CH₂Cl₂ / 12 h / 20 °C

2: 78 percent / HCl / ethanol / 2 h / 20 °C

With pyridine; hydrogenchloride; In ethanol; dichloromethane;

DOI:10.1016/j.bmcl.2006.10.036

upstream raw materials:

7-(4'-chloro-2-methyl-biphenyl-4-sulfonylamino)-1,2,4,5-tetrahydro-benzo[d]azepine-3-carboxylic acid tert-butyl ester

7-amino-1,2,4,5-tetrahydro-benzo[d]azepine-3-carboxylic acid tert-butyl ester