(±)-(3aR,4R,7aS)-6-methyl-4-phenyl-3a,4,7,7a-tetrahydroisobenzofuran-1,3-dion

Base Information

Chemical Name:(±)-(3aR,4R,7aS)-6-methyl-4-phenyl-3a,4,7,7a-tetrahydroisobenzofuran-1,3-dion
CAS No.:108474-12-0
Molecular Formula:C₁₅H₁₄O₃
Molecular Weight:242.274
Hs Code.:

Synonyms:(±)-(3aR,4R,7aS)-6-methyl-4-phenyl-3a,4,7,7a-tetrahydroisobenzofuran-1,3-dion

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (±)-(3aR,4R,7aS)-6-methyl-4-phenyl-3a,4,7,7a-tetrahydroisobenzofuran-1,3-dion

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Technology Process of (±)-(3aR,4R,7aS)-6-methyl-4-phenyl-3a,4,7,7a-tetrahydroisobenzofuran-1,3-dion

There total 4 articles about (±)-(3aR,4R,7aS)-6-methyl-4-phenyl-3a,4,7,7a-tetrahydroisobenzofuran-1,3-dion which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 108-31-6
maleic anhydride

: 4489-84-3
3-methyl-1-phenylbut-2-ene

: 108474-12-0
(±)-(3aR,4R,7aS)-6-methyl-4-phenyl-3a,4,7,7a-tetrahydroisobenzofuran-1,3-dion

Guidance literature:: With 2,3-dicyano-5,6-dichloro-p-benzoquinone; lithium chloride; In toluene; at 115 ℃; for 72h; Inert atmosphere; Sealed tube;
DOI:10.1021/acs.orglett.8b02469

Reference yield:

: 122-78-1
phenylacetaldehyde

: 108474-12-0
(±)-(3aR,4R,7aS)-6-methyl-4-phenyl-3a,4,7,7a-tetrahydroisobenzofuran-1,3-dion

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / 0 °C

1.2: 20 °C

2.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone; lithium chloride / toluene / 72 h / 115 °C / Inert atmosphere; Sealed tube

With n-butyllithium; 2,3-dicyano-5,6-dichloro-p-benzoquinone; lithium chloride; In tetrahydrofuran; hexane; toluene;
DOI:10.1021/acs.orglett.8b02469