(2E)-3-{2-[(1R)-1-({(2R)-3-[(2S)-2-(3-fluoro-4-methylbenzyl) pyrrolidin-1-yl]-2-hydroxypropyl}oxy)ethyl]phenyl}prop-2-enoic acid

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Chemical Name:(2E)-3-{2-[(1R)-1-({(2R)-3-[(2S)-2-(3-fluoro-4-methylbenzyl) pyrrolidin-1-yl]-2-hydroxypropyl}oxy)ethyl]phenyl}prop-2-enoic acid
CAS No.:1232828-84-0
Molecular Formula:C₂₆H₃₂FNO₄
Molecular Weight:441.543
Hs Code.:

Synonyms:(2E)-3-{2-[(1R)-1-({(2R)-3-[(2S)-2-(3-fluoro-4-methylbenzyl) pyrrolidin-1-yl]-2-hydroxypropyl}oxy)ethyl]phenyl}prop-2-enoic acid

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Chemical Property of (2E)-3-{2-[(1R)-1-({(2R)-3-[(2S)-2-(3-fluoro-4-methylbenzyl) pyrrolidin-1-yl]-2-hydroxypropyl}oxy)ethyl]phenyl}prop-2-enoic acid

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Technology Process of (2E)-3-{2-[(1R)-1-({(2R)-3-[(2S)-2-(3-fluoro-4-methylbenzyl) pyrrolidin-1-yl]-2-hydroxypropyl}oxy)ethyl]phenyl}prop-2-enoic acid

There total 8 articles about (2E)-3-{2-[(1R)-1-({(2R)-3-[(2S)-2-(3-fluoro-4-methylbenzyl) pyrrolidin-1-yl]-2-hydroxypropyl}oxy)ethyl]phenyl}prop-2-enoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1232828-90-8
methyl (2E)-3-{2-[(1R)-1-({(2R)-3-[(2S)-2-(3-fluoro-4-methylbenzyl)pyrrolidin-1-yl]-2-hydroxypropyl}oxy)ethyl]phenyl}prop-2-enoate

: 1232828-84-0
(2E)-3-{2-[(1R)-1-({(2R)-3-[(2S)-2-(3-fluoro-4-methylbenzyl) pyrrolidin-1-yl]-2-hydroxypropyl}oxy)ethyl]phenyl}prop-2-enoic acid

Guidance literature:: methyl (2E)-3-{2-[(1R)-1-({(2R)-3-[(2S)-2-(3-fluoro-4-methylbenzyl)pyrrolidin-1-yl]-2-hydroxypropyl}oxy)ethyl]phenyl}prop-2-enoate; With water; sodium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 16h;

With hydrogenchloride; In water;

Reference yield:

: 1232828-85-1
tert-butyl (2S)-2-(3-fluoro-4-methylbenzoyl)pyrrolidine-1-carboxylate

: 1232828-84-0
(2E)-3-{2-[(1R)-1-({(2R)-3-[(2S)-2-(3-fluoro-4-methylbenzyl) pyrrolidin-1-yl]-2-hydroxypropyl}oxy)ethyl]phenyl}prop-2-enoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: sodium tetrahydroborate; methanol / 0.5 h / 20 °C / Cooling with ice

2: dmap / tetrahydrofuran / 16 h / Reflux

3: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / toluene / 6 h / Reflux

4: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

5: lithium perchlorate / toluene / 16 h / 20 °C

6: sodium hydroxide; water / tetrahydrofuran; methanol / 16 h / 20 °C

With methanol; dmap; sodium tetrahydroborate; 2,2'-azobis(isobutyronitrile); water; tri-n-butyl-tin hydride; lithium perchlorate; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; toluene;

Reference yield:

: 115186-37-3
tert-butyl (2S)-2-{[N-methoxy(N-methyl)amino]carbonyl}pyrrolidine-1-carboxylate

: 1232828-84-0
(2E)-3-{2-[(1R)-1-({(2R)-3-[(2S)-2-(3-fluoro-4-methylbenzyl) pyrrolidin-1-yl]-2-hydroxypropyl}oxy)ethyl]phenyl}prop-2-enoic acid

Guidance literature:: Multi-step reaction with 7 steps

1: tetrahydrofuran / 16 h / 20 °C / Inert atmosphere; Cooling with ice

2: sodium tetrahydroborate; methanol / 0.5 h / 20 °C / Cooling with ice

3: dmap / tetrahydrofuran / 16 h / Reflux

4: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / toluene / 6 h / Reflux

5: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

6: lithium perchlorate / toluene / 16 h / 20 °C

7: sodium hydroxide; water / tetrahydrofuran; methanol / 16 h / 20 °C

With methanol; dmap; sodium tetrahydroborate; 2,2'-azobis(isobutyronitrile); water; tri-n-butyl-tin hydride; lithium perchlorate; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; toluene;