(1S,2S,6R)-2-isobutoxycarboxymethyl-7-methylidene-3-oxa-9-tosylamidobicyclo<4.3.0>non-4-ene

Base Information

Chemical Name:(1S,2S,6R)-2-isobutoxycarboxymethyl-7-methylidene-3-oxa-9-tosylamidobicyclo<4.3.0>non-4-ene
CAS No.:134769-04-3
Molecular Formula:C₂₁H₂₇NO₆S
Molecular Weight:421.514
Hs Code.:

Synonyms:(1S,2S,6R)-2-isobutoxycarboxymethyl-7-methylidene-3-oxa-9-tosylamidobicyclo<4.3.0>non-4-ene

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Chemical Property of (1S,2S,6R)-2-isobutoxycarboxymethyl-7-methylidene-3-oxa-9-tosylamidobicyclo<4.3.0>non-4-ene

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Technology Process of (1S,2S,6R)-2-isobutoxycarboxymethyl-7-methylidene-3-oxa-9-tosylamidobicyclo<4.3.0>non-4-ene

There total 7 articles about (1S,2S,6R)-2-isobutoxycarboxymethyl-7-methylidene-3-oxa-9-tosylamidobicyclo<4.3.0>non-4-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 134768-97-1
isopropyl 6-O-(isobutoxycarbonyl)-4--2,3,4-trideoxy-α-D-erythro-hex-2-enopyranoside

: 134769-04-3
(1S,2S,6R)-2-isobutoxycarboxymethyl-7-methylidene-3-oxa-9-tosylamidobicyclo<4.3.0>non-4-ene

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; triphenylphosphine; In acetic acid; at 80 ℃; for 2h;
DOI:10.1016/S0040-4020(97)00012-4

Reference yield:

: 134768-99-3
Carbonic acid isobutyl ester (2S,3S)-3-[prop-2-ynyl-(toluene-4-sulfonyl)-amino]-3,6-dihydro-2H-pyran-2-ylmethyl ester

: 134769-04-3
(1S,2S,6R)-2-isobutoxycarboxymethyl-7-methylidene-3-oxa-9-tosylamidobicyclo<4.3.0>non-4-ene

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In acetic acid; at 80 ℃;
DOI:10.1016/S0040-4039(00)71264-0

Reference yield:

: 134768-92-6
Carbonic acid (2R,3S,6S)-2-isobutoxycarbonyloxymethyl-6-isopropoxy-3,6-dihydro-2H-pyran-3-yl ester isobutyl ester

: 134769-04-3
(1S,2S,6R)-2-isobutoxycarboxymethyl-7-methylidene-3-oxa-9-tosylamidobicyclo<4.3.0>non-4-ene

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / Pd(PPh₃)4, PPh₃ / tetrahydrofuran / 6 h / Heating

2: 92 percent / Bu₄NI, NaN(SiMe₃)2 / tetrahydrofuran / Ambient temperature

3: 84 percent / Pd(PPh₃)4, PPh₃ / acetic acid / 2 h / 80 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hexamethyldisilazane; tetra-(n-butyl)ammonium iodide; triphenylphosphine; In tetrahydrofuran; acetic acid;
DOI:10.1016/S0040-4020(97)00012-4