(E)-1-(4-(1H-imidazol-1-yl)phenyl)-3-(4-(2,5-difluorobenzyloxy)phenyl)prop-2-en-1-one

Base Information

• Chemical Name: (E)-1-(4-(1H-imidazol-1-yl)phenyl)-3-(4-(2,5-difluorobenzyloxy)phenyl)prop-2-en-1-one
• CAS No.: 1334928-99-2
• Molecular Formula: C₂₅H₁₈F₂N₂O₂
• Molecular Weight: 416.427
• Mol file: 1334928-99-2.mol

Synonyms:(E)-1-(4-(1H-imidazol-1-yl)phenyl)-3-(4-(2,5-difluorobenzyloxy)phenyl)prop-2-en-1-one

Chemical Property of (E)-1-(4-(1H-imidazol-1-yl)phenyl)-3-(4-(2,5-difluorobenzyloxy)phenyl)prop-2-en-1-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-1-(4-(1H-imidazol-1-yl)phenyl)-3-(4-(2,5-difluorobenzyloxy)phenyl)prop-2-en-1-one

There total 4 articles about (E)-1-(4-(1H-imidazol-1-yl)phenyl)-3-(4-(2,5-difluorobenzyloxy)phenyl)prop-2-en-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

4-(2,5-difluorobenzyloxy)benzaldehyde (1272111-71-3) + 4'-(imidazol-1-yl)acetophenone (10041-06-2) → (E)-1-(4-(1H-imidazol-1-yl)phenyl)-3-(4-(2,5-difluorobenzyloxy)phenyl)prop-2-en-1-one (1334928-99-2)

Guidance literature:

With sodium hydroxide; In ethanol; at 20 ℃;

DOI:10.1016/j.ejmech.2011.06.037

Reference yield:

1-(4-fluorophenyl)ethanone (403-42-9) → (E)-1-(4-(1H-imidazol-1-yl)phenyl)-3-(4-(2,5-difluorobenzyloxy)phenyl)prop-2-en-1-one (1334928-99-2)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 110 °C

2: sodium hydroxide / ethanol / 20 °C

With potassium carbonate; sodium hydroxide; In ethanol; N,N-dimethyl-formamide; 2: Claisen-Schmidt condensation;

DOI:10.1016/j.ejmech.2011.06.037

Reference yield:

4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → (E)-1-(4-(1H-imidazol-1-yl)phenyl)-3-(4-(2,5-difluorobenzyloxy)phenyl)prop-2-en-1-one (1334928-99-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium tert-butylate / dimethyl sulfoxide / 0.67 h / 5 - 10 °C

1.2: 5 - 20 °C

2.1: sodium hydroxide / ethanol / 20 °C

With potassium tert-butylate; sodium hydroxide; In ethanol; dimethyl sulfoxide; 2.1: Claisen-Schmidt condensation;

DOI:10.1016/j.ejmech.2011.06.037

upstream raw materials:

4-(2,5-difluorobenzyloxy)benzaldehyde

4'-(imidazol-1-yl)acetophenone

1-(4-fluorophenyl)ethanone

4-hydroxy-benzaldehyde