1-[5-[bis(1-methylethyl)(phenylmethoxy)silyl]-2-(methoxymethoxy)phenyl]-2-phenylethanol

Base Information

• Chemical Name: 1-[5-[bis(1-methylethyl)(phenylmethoxy)silyl]-2-(methoxymethoxy)phenyl]-2-phenylethanol
• CAS No.: 261960-79-6
• Molecular Formula: C₂₉H₃₈O₄Si
• Molecular Weight: 478.704
• Mol file: 261960-79-6.mol

Synonyms:1-[5-[bis(1-methylethyl)(phenylmethoxy)silyl]-2-(methoxymethoxy)phenyl]-2-phenylethanol

Chemical Property of 1-[5-[bis(1-methylethyl)(phenylmethoxy)silyl]-2-(methoxymethoxy)phenyl]-2-phenylethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[5-[bis(1-methylethyl)(phenylmethoxy)silyl]-2-(methoxymethoxy)phenyl]-2-phenylethanol

There total 1 articles about 1-[5-[bis(1-methylethyl)(phenylmethoxy)silyl]-2-(methoxymethoxy)phenyl]-2-phenylethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

5-[bis(1-methylethyl)(phenylmethoxy)silyl]-2-(methoxymethoxy)benzaldehyde (181773-35-3) + benzylmagnesium chloride (6921-34-2) → 1-[5-[bis(1-methylethyl)(phenylmethoxy)silyl]-2-(methoxymethoxy)phenyl]-2-phenylethanol (261960-79-6)

Guidance literature:

In tetrahydrofuran; at 25 ℃; for 4h;

DOI:10.1016/S0040-4020(99)01045-5

Reference yield: 90.0%

1-[5-[bis(1-methylethyl)(phenylmethoxy)silyl]-2-(methoxymethoxy)phenyl]-2-phenylethanol (261960-79-6) → 1-[5-[bis(1-methylethyl)(phenylmethoxy)silyl]-2-(methoxymethoxy)phenyl]-2-phenylethanone (261960-68-3)

Guidance literature:

With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; at -78 - 25 ℃;

DOI:10.1016/S0040-4020(99)01045-5

Reference yield:

1-[5-[bis(1-methylethyl)(phenylmethoxy)silyl]-2-(methoxymethoxy)phenyl]-2-phenylethanol (261960-79-6) → 2-methyl-3-phenyl-4H-1-benzopyran-4-one (24258-66-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 90 percent / DMSO; (COCl)2; Et₃N / CH₂Cl₂ / -78 - 25 °C

2: 94 percent / TFA / CH₂Cl₂ / 1 h / 0 °C

3: 85 percent / tetrahydrofuran / 6 h / 40 °C

4: 84 percent / TBAF / tetrahydrofuran / 0.5 h / 45 °C

With oxalyl dichloride; tetrabutyl ammonium fluoride; dimethyl sulfoxide; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; 1: Swern oxidation / 2: Substitution / 3: cyclocondensation / 4: Substitution;

DOI:10.1016/S0040-4020(99)01045-5

upstream raw materials:

5-[bis(1-methylethyl)(phenylmethoxy)silyl]-2-(methoxymethoxy)benzaldehyde

benzylmagnesium chloride

Downstream raw materials:

1-[5-[bis(1-methylethyl)(phenylmethoxy)silyl]-2-(methoxymethoxy)phenyl]-2-phenylethanone

2-methyl-3-phenyl-4H-1-benzopyran-4-one

1-[5-[bis(1-methylethyl)(phenylmethoxy)silyl]-2-(hydroxy)phenyl]-2-phenylethanone

6-[bis(1-methylethyl)(phenylmethoxy)silyl]-2-methyl-3-phenyl-4H-1-benzopyran-4-one