Technology Process of C18H25NOS
There total 10 articles about C18H25NOS which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
Lawessons reagent;
In
toluene;
at 60 ℃;
for 1h;
Inert atmosphere;
DOI:10.1021/ol201704g
- Guidance literature:
-
Multi-step reaction with 9 steps
1: tetrahydrofuran; toluene / 3.5 h / -78 °C / Inert atmosphere
2: hydrogenchloride; water / methanol / 2 h
3: potassium carbonate / water; acetone; toluene / 1 h / 20 °C
4: Hoveyda-Grubbs catalyst second generation / dichloromethane / 1 h / 20 °C / Inert atmosphere
5: boron trifluoride diethyl etherate / acetonitrile / 1 h / 20 °C / Inert atmosphere
6: benzene / 16 h / 20 °C / Inert atmosphere
7: palladium 10% on activated carbon; hydrogen / ethyl acetate / 18 h / 20 °C / 760.05 Torr
8: 5,5-dimethyl-1,3-cyclohexadiene / 12 h / 144 °C / Microwave irradiation; Sealed tube
9: Lawessons reagent / toluene / 1 h / 60 °C / Inert atmosphere
With
Lawessons reagent; hydrogenchloride; Hoveyda-Grubbs catalyst second generation; palladium 10% on activated carbon; boron trifluoride diethyl etherate; water; hydrogen; potassium carbonate;
In
tetrahydrofuran; methanol; 5,5-dimethyl-1,3-cyclohexadiene; dichloromethane; water; ethyl acetate; acetone; toluene; acetonitrile; benzene;
1: Grignard addition / 5: Michael addition;
DOI:10.1021/ol201704g
- Guidance literature:
-
Multi-step reaction with 3 steps
1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 18 h / 20 °C / 760.05 Torr
2: 5,5-dimethyl-1,3-cyclohexadiene / 12 h / 144 °C / Microwave irradiation; Sealed tube
3: Lawessons reagent / toluene / 1 h / 60 °C / Inert atmosphere
With
Lawessons reagent; palladium 10% on activated carbon; hydrogen;
In
5,5-dimethyl-1,3-cyclohexadiene; ethyl acetate; toluene;
DOI:10.1021/ol201704g
