6-{3-chloro-4-[cyclopropyl(hydroxy)methyl]phenyl}pyrimidine-4-carboxylic acid

Base Information

Chemical Name:6-{3-chloro-4-[cyclopropyl(hydroxy)methyl]phenyl}pyrimidine-4-carboxylic acid
CAS No.:1426320-15-1
Molecular Formula:C₁₅H₁₃ClN₂O₃
Molecular Weight:304.733
Hs Code.:

Synonyms:6-{3-chloro-4-[cyclopropyl(hydroxy)methyl]phenyl}pyrimidine-4-carboxylic acid

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Chemical Property of 6-{3-chloro-4-[cyclopropyl(hydroxy)methyl]phenyl}pyrimidine-4-carboxylic acid

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Technology Process of 6-{3-chloro-4-[cyclopropyl(hydroxy)methyl]phenyl}pyrimidine-4-carboxylic acid

There total 3 articles about 6-{3-chloro-4-[cyclopropyl(hydroxy)methyl]phenyl}pyrimidine-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 1426320-85-5
ethyl 6-{3-chloro-4-[cyclopropyl(hydroxy)methyl]phenyl}pyrimidine-4-carboxylate

: 1426320-15-1
6-{3-chloro-4-[cyclopropyl(hydroxy)methyl]phenyl}pyrimidine-4-carboxylic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; at 20 ℃; for 16h;

Reference yield:

: 1426320-83-3
(4-bromo-2-chlorophenyl)(cyclopropyl)methanol

: 1426320-15-1
6-{3-chloro-4-[cyclopropyl(hydroxy)methyl]phenyl}pyrimidine-4-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium acetate / dimethyl sulfoxide / 16 h / 80 °C / Inert atmosphere

2: potassium phosphate; palladium bis[bis(diphenylphosphino)ferrocene] dichloride / N,N-dimethyl-formamide / 16 h / 60 °C / Inert atmosphere

3: sodium hydroxide / tetrahydrofuran / 16 h / 20 °C

With potassium phosphate; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium acetate; sodium hydroxide; In tetrahydrofuran; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 1426320-84-4
[2-chloro-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl](cyclopropyl)methanol

: 1426320-15-1
6-{3-chloro-4-[cyclopropyl(hydroxy)methyl]phenyl}pyrimidine-4-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: potassium phosphate; palladium bis[bis(diphenylphosphino)ferrocene] dichloride / N,N-dimethyl-formamide / 16 h / 60 °C / Inert atmosphere

2: sodium hydroxide / tetrahydrofuran / 16 h / 20 °C

With potassium phosphate; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;