5-(tert-Butyl-diphenyl-silanyloxymethyl)-isophthalic acid bis-[(R)-2-((R)-2-carboxy-1-methyl-ethoxycarbonyl)-1-methyl-ethyl] ester

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Chemical Name:5-(tert-Butyl-diphenyl-silanyloxymethyl)-isophthalic acid bis-[(R)-2-((R)-2-carboxy-1-methyl-ethoxycarbonyl)-1-methyl-ethyl] ester
CAS No.:193953-23-0
Molecular Formula:C₄₁H₅₀O₁₃Si
Molecular Weight:778.926
Hs Code.:

Synonyms:5-(tert-Butyl-diphenyl-silanyloxymethyl)-isophthalic acid bis-[(R)-2-((R)-2-carboxy-1-methyl-ethoxycarbonyl)-1-methyl-ethyl] ester

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Chemical Property of 5-(tert-Butyl-diphenyl-silanyloxymethyl)-isophthalic acid bis-[(R)-2-((R)-2-carboxy-1-methyl-ethoxycarbonyl)-1-methyl-ethyl] ester

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Technology Process of 5-(tert-Butyl-diphenyl-silanyloxymethyl)-isophthalic acid bis-[(R)-2-((R)-2-carboxy-1-methyl-ethoxycarbonyl)-1-methyl-ethyl] ester

There total 6 articles about 5-(tert-Butyl-diphenyl-silanyloxymethyl)-isophthalic acid bis-[(R)-2-((R)-2-carboxy-1-methyl-ethoxycarbonyl)-1-methyl-ethyl] ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 5-(tert-Butyl-diphenyl-silanyloxymethyl)-isophthalic acid bis-[(R)-2-((R)-2-benzyloxycarbonyl-1-methyl-ethoxycarbonyl)-1-methyl-ethyl] ester; compound with 2,2,2-trifluoro-ethanol

: 193953-23-0
5-(tert-Butyl-diphenyl-silanyloxymethyl)-isophthalic acid bis-[(R)-2-((R)-2-carboxy-1-methyl-ethoxycarbonyl)-1-methyl-ethyl] ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In various solvent(s);
DOI:10.1002/hlca.19970800402

Reference yield:

: 109862-53-5
dimethyl 5-hydroxymethylbenzene-1,3-dicarboxylate

: 193953-23-0
5-(tert-Butyl-diphenyl-silanyloxymethyl)-isophthalic acid bis-[(R)-2-((R)-2-carboxy-1-methyl-ethoxycarbonyl)-1-methyl-ethyl] ester

Guidance literature:: Multi-step reaction with 5 steps

1: 92.8 percent / DMAP / dimethylformamide / 24 h / Ambient temperature

2: 78 percent / LiOH / methanol; dioxane; H₂O / 0.5 h

3: (COCl)2 / dimethylformamide / 14 h

4: pyridine, (t-Bu)Ph₂SiF / CH₂Cl₂ / 0 deg C, 3 h, RT, 8 h

5: 98 percent / H₂ / 10 percent Pd/C / various solvent(s)

With pyridine; dmap; lithium hydroxide; oxalyl dichloride; hydrogen; tert-butyl diphenylfluorosilane; palladium on activated charcoal; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1002/hlca.19970800402

Reference yield:

: 186351-30-4
5-(tert-Butyl-diphenyl-silanyloxymethyl)-isophthaloyl dichloride

: 193953-23-0
5-(tert-Butyl-diphenyl-silanyloxymethyl)-isophthalic acid bis-[(R)-2-((R)-2-carboxy-1-methyl-ethoxycarbonyl)-1-methyl-ethyl] ester

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine, (t-Bu)Ph₂SiF / CH₂Cl₂ / 0 deg C, 3 h, RT, 8 h

2: 98 percent / H₂ / 10 percent Pd/C / various solvent(s)

With pyridine; hydrogen; tert-butyl diphenylfluorosilane; palladium on activated charcoal; In dichloromethane;
DOI:10.1002/hlca.19970800402