3,5-Bis-[3,5-bis-(4-methoxycarbonyl-benzyloxy)-benzyloxy]-benzoic acid 2,2,2-trichloro-ethyl ester

Base Information

• Chemical Name: 3,5-Bis-[3,5-bis-(4-methoxycarbonyl-benzyloxy)-benzyloxy]-benzoic acid 2,2,2-trichloro-ethyl ester
• CAS No.: 628685-36-9
• Molecular Formula: C₅₉H₅₁Cl₃O₁₆
• Molecular Weight: 1122.4
• Mol file: 628685-36-9.mol

Synonyms:3,5-Bis-[3,5-bis-(4-methoxycarbonyl-benzyloxy)-benzyloxy]-benzoic acid 2,2,2-trichloro-ethyl ester

Chemical Property of 3,5-Bis-[3,5-bis-(4-methoxycarbonyl-benzyloxy)-benzyloxy]-benzoic acid 2,2,2-trichloro-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,5-Bis-[3,5-bis-(4-methoxycarbonyl-benzyloxy)-benzyloxy]-benzoic acid 2,2,2-trichloro-ethyl ester

There total 1 articles about 3,5-Bis-[3,5-bis-(4-methoxycarbonyl-benzyloxy)-benzyloxy]-benzoic acid 2,2,2-trichloro-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

2',2',2'-trichloroethyl 3,5-dihydroxybenzoate (143330-91-0) + 3,5-bis[4-(methoxycarbonyl)phenylmethyl]benzyl bromide (150550-99-5) → 3,5-Bis-[3,5-bis-(4-methoxycarbonyl-benzyloxy)-benzyloxy]-benzoic acid 2,2,2-trichloro-ethyl ester (628685-36-9)

Guidance literature:

With 18-crown-6 ether; potassium carbonate; In tetrahydrofuran; for 48h; Heating;

DOI:10.1021/ma034221b

Reference yield: 50.0%

3,5-Bis-[3,5-bis-(4-methoxycarbonyl-benzyloxy)-benzyloxy]-benzoic acid 2,2,2-trichloro-ethyl ester (628685-36-9) → 3,5-Bis-[3,5-bis-(4-methoxycarbonyl-benzyloxy)-benzyloxy]-benzoic acid (628685-37-0)

Guidance literature:

With acetic acid; zinc; In tetrahydrofuran; at 25 ℃; for 0.333333h;

DOI:10.1021/ma034221b

Reference yield:

3,5-Bis-[3,5-bis-(4-methoxycarbonyl-benzyloxy)-benzyloxy]-benzoic acid 2,2,2-trichloro-ethyl ester (628685-36-9) → C71H65Cl3N2O18

Guidance literature:

Multi-step reaction with 2 steps

1: 50 percent / Zn; AcOH / tetrahydrofuran / 0.33 h / 25 °C

2: 51 percent / benzotriazol-1-ol; N,N'-dicyclohexylcarbodiimide; 2,4,6-collidine / dimethylformamide / 23 h / 0 - 25 °C

With 2,4,6-trimethyl-pyridine; benzotriazol-1-ol; acetic acid; dicyclohexyl-carbodiimide; zinc; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/ma034221b

upstream raw materials:

2',2',2'-trichloroethyl 3,5-dihydroxybenzoate

3,5-bis[4-(methoxycarbonyl)phenylmethyl]benzyl bromide

Downstream raw materials:

3,5-Bis-[3,5-bis-(4-methoxycarbonyl-benzyloxy)-benzyloxy]-benzoic acid