Chemical Property of C19-H17-N5-O7-S3.Cl-H
Chemical Property:
- Appearance/Colour:Off-white solid
- Vapor Pressure:5.14E-28mmHg at 25°C
- Melting Point:>190°C (dec.)
- Boiling Point:814.1 °C at 760 mmHg
- Flash Point:446.1 °C
- PSA：256.26000
- LogP:2.69300
- Storage Temp.:-20°C Freezer
- Solubility.:DMSO (Slightly), Methanol (Slightly)
- Hydrogen Bond Donor Count:4
- Hydrogen Bond Acceptor Count:13
- Rotatable Bond Count:9
- Exact Mass:559.0056891
- Heavy Atom Count:35
- Complexity:945
- Purity/Quality:
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Not less than 98% *data from raw suppliers
Ceftiofur hydrochloride
*data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CON=C(C1=CSC(=N1)N)C(=O)NC2C3N(C2=O)C(=C(CS3)CSC(=O)C4=CC=CO4)C(=O)O.Cl
- Isomeric SMILES:CO/N=C(\C1=CSC(=N1)N)/C(=O)N[C@H]2[C@H]3N(C2=O)C(=C(CS3)CSC(=O)C4=CC=CO4)C(=O)O.Cl
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Description
Ceftiofur Hydrochloride is the hydrochloride salt form of ceftiofur, a semisynthetic, beta-lactamase-stable, broad-spectrum, third-generation cephalosporin with antibacterial activity. Ceftiofur binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.
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Uses
An antibacterial. Ceftiofur hydrochloride (ceftiofur) has been approved for treatment against respiratory diseases in many animals.1,3,8–10 The recommended dosage regimen of ceftiofur for the treatment of swine respiratory disease is 3–5 mg/kg body weight (BW) administered intramuscularly once daily for 3–5 consecutive days.
