1-methyl-4-(2-methyl-4-methylsulfonylphenyl)-3-(2-pyridyl)-4,6,7,8-tetrahydropyrazolo[3,4-e][1,4]thiazepine

Base Information

Chemical Name:1-methyl-4-(2-methyl-4-methylsulfonylphenyl)-3-(2-pyridyl)-4,6,7,8-tetrahydropyrazolo[3,4-e][1,4]thiazepine
CAS No.:1616359-90-0
Molecular Formula:C₂₀H₂₂N₄O₂S₂
Molecular Weight:414.552
Hs Code.:

Synonyms:1-methyl-4-(2-methyl-4-methylsulfonylphenyl)-3-(2-pyridyl)-4,6,7,8-tetrahydropyrazolo[3,4-e][1,4]thiazepine

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Chemical Property of 1-methyl-4-(2-methyl-4-methylsulfonylphenyl)-3-(2-pyridyl)-4,6,7,8-tetrahydropyrazolo[3,4-e][1,4]thiazepine

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Technology Process of 1-methyl-4-(2-methyl-4-methylsulfonylphenyl)-3-(2-pyridyl)-4,6,7,8-tetrahydropyrazolo[3,4-e][1,4]thiazepine

There total 5 articles about 1-methyl-4-(2-methyl-4-methylsulfonylphenyl)-3-(2-pyridyl)-4,6,7,8-tetrahydropyrazolo[3,4-e][1,4]thiazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 3.0%

: 1616359-91-1
4-(4-bromo-2-methylphenyl)-1-methyl-3-(2-pyridyl)-4,6,7,8-tetrahydropyrazolo[3,4-e][1,4]thiazepine

: 20277-69-4
sodium methansulfinate

: 1616359-90-0
1-methyl-4-(2-methyl-4-methylsulfonylphenyl)-3-(2-pyridyl)-4,6,7,8-tetrahydropyrazolo[3,4-e][1,4]thiazepine

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In toluene; at 120 ℃;

Reference yield:

: 92406-50-3
1-methyl-3-(pyridin-2-yl)-1H-pyrazol-5-amine

: 1616359-90-0
1-methyl-4-(2-methyl-4-methylsulfonylphenyl)-3-(2-pyridyl)-4,6,7,8-tetrahydropyrazolo[3,4-e][1,4]thiazepine

Guidance literature:: Multi-step reaction with 3 steps

1: acetonitrile / 0.42 h / 150 °C / Sealed tube; Microwave irradiation

2: borane-THF / tetrahydrofuran / 0 - 20 °C

3: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate / toluene / 120 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; borane-THF; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; toluene; acetonitrile;

Reference yield:

: 54123-21-6
3-(pyridine-2-yl)-3-oxopropanenitrile

: 1616359-90-0
1-methyl-4-(2-methyl-4-methylsulfonylphenyl)-3-(2-pyridyl)-4,6,7,8-tetrahydropyrazolo[3,4-e][1,4]thiazepine

Guidance literature:: Multi-step reaction with 4 steps

1: ethanol / 18.5 h / 20 - 75 °C

2: acetonitrile / 0.42 h / 150 °C / Sealed tube; Microwave irradiation

3: borane-THF / tetrahydrofuran / 0 - 20 °C

4: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate / toluene / 120 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; borane-THF; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; ethanol; toluene; acetonitrile;