4-[1-Thiophen-2-yl-1-p-tolyl-meth-(E)-ylidene]-tetrahydro-pyridazine-3,6-dione

Base Information

Chemical Name:4-[1-Thiophen-2-yl-1-p-tolyl-meth-(E)-ylidene]-tetrahydro-pyridazine-3,6-dione
CAS No.:81541-45-9
Molecular Formula:C₁₆H₁₄N₂O₂S
Molecular Weight:298.365
Hs Code.:

Synonyms:4-[1-Thiophen-2-yl-1-p-tolyl-meth-(E)-ylidene]-tetrahydro-pyridazine-3,6-dione

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Chemical Property of 4-[1-Thiophen-2-yl-1-p-tolyl-meth-(E)-ylidene]-tetrahydro-pyridazine-3,6-dione

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Technology Process of 4-[1-Thiophen-2-yl-1-p-tolyl-meth-(E)-ylidene]-tetrahydro-pyridazine-3,6-dione

There total 3 articles about 4-[1-Thiophen-2-yl-1-p-tolyl-meth-(E)-ylidene]-tetrahydro-pyridazine-3,6-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 81541-43-7
2-[1-Thiophen-2-yl-1-p-tolyl-meth-(E)-ylidene]-succinic acid

: 81541-45-9
4-[1-Thiophen-2-yl-1-p-tolyl-meth-(E)-ylidene]-tetrahydro-pyridazine-3,6-dione

Guidance literature:: With hydrazine hydrate; In ethanol; for 2h;
DOI:10.1002/jhet.5570180805

Reference yield: 42.0%

: 81541-44-8
trans-(SC₄H₃/CO₂Me)-3-methoxycarbonyl-4-(p-tolyl)-4-(2'-thienyl)but-3-enoic acid

: 81541-45-9
4-[1-Thiophen-2-yl-1-p-tolyl-meth-(E)-ylidene]-tetrahydro-pyridazine-3,6-dione

Guidance literature:: With hydrazine hydrate; In ethanol; 1.)heating, 30 min 2.)overnight;
DOI:10.1002/jhet.5570180805

Reference yield:

: 6933-25-1
2-thienyl 4-methylphenyl ketone

: 81541-45-9
4-[1-Thiophen-2-yl-1-p-tolyl-meth-(E)-ylidene]-tetrahydro-pyridazine-3,6-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / t-BuOK / 2-methyl-propan-2-ol / 1 h

2: 77 percent / 10percent aq. NaOH

3: 71 percent / N₂H₄*H₂O / ethanol / 2 h

With sodium hydroxide; potassium tert-butylate; hydrazine hydrate; In ethanol; tert-butyl alcohol;
DOI:10.1002/jhet.5570180805