6-(2-acetoxyethyl)-4-(2-azidophenyl)-7,8-dihydroquinoline-7,8-dione

Base Information

• Chemical Name: 6-(2-acetoxyethyl)-4-(2-azidophenyl)-7,8-dihydroquinoline-7,8-dione
• CAS No.: 128350-23-2
• Molecular Formula: C₁₉H₁₄N₄O₄
• Molecular Weight: 362.345
• Mol file: 128350-23-2.mol

Synonyms:6-(2-acetoxyethyl)-4-(2-azidophenyl)-7,8-dihydroquinoline-7,8-dione

Chemical Property of 6-(2-acetoxyethyl)-4-(2-azidophenyl)-7,8-dihydroquinoline-7,8-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-(2-acetoxyethyl)-4-(2-azidophenyl)-7,8-dihydroquinoline-7,8-dione

There total 3 articles about 6-(2-acetoxyethyl)-4-(2-azidophenyl)-7,8-dihydroquinoline-7,8-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

6-(2-acetoxyethyl)-4-(2-azidophenyl)-8-hydroxyquinoline (128367-82-8) → 6-(2-acetoxyethyl)-4-(2-azidophenyl)-7,8-dihydroquinoline-7,8-dione (128350-23-2)

Guidance literature:

With phosphate buffer; potassiuim nitrosodisulfonate; In methanol; at 25 ℃;

DOI:10.1016/S0040-4039(01)93799-2

Reference yield:

Acetic acid 6-(2-acetoxy-ethyl)-4-(2-azido-phenyl)-quinolin-8-yl ester (128367-85-1) → 6-(2-acetoxyethyl)-4-(2-azidophenyl)-7,8-dihydroquinoline-7,8-dione (128350-23-2)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NaHCO₃ / methanol

2: 56 percent / potassium nitrosodisulfonate, 0.5 M KH₂PO₄ buffer / methanol / 3.5 h / Ambient temperature

With KH₂PO₄ buffer; potassiuim nitrosodisulfonate; sodium hydrogencarbonate; In methanol;

DOI:10.1021/ja00021a031

Reference yield:

Acetic acid 6-(2-acetoxy-ethyl)-4-(2-azido-phenyl)-5,6-dihydro-quinolin-8-yl ester (135761-81-8) → 6-(2-acetoxyethyl)-4-(2-azidophenyl)-7,8-dihydroquinoline-7,8-dione (128350-23-2)

Guidance literature:

Multi-step reaction with 3 steps

1: DDQ / toluene / 0.5 h / Heating

2: aq. NaHCO₃ / methanol

3: 56 percent / potassium nitrosodisulfonate, 0.5 M KH₂PO₄ buffer / methanol / 3.5 h / Ambient temperature

With KH₂PO₄ buffer; potassiuim nitrosodisulfonate; sodium hydrogencarbonate; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In methanol; toluene;

DOI:10.1021/ja00021a031

upstream raw materials:

6-(2-acetoxyethyl)-4-(2-azidophenyl)-8-hydroxyquinoline

Acetic acid 6-(2-acetoxy-ethyl)-4-(2-azido-phenyl)-quinolin-8-yl ester

Acetic acid 6-(2-acetoxy-ethyl)-4-(2-azido-phenyl)-5,6-dihydro-quinolin-8-yl ester