methyl 4-{[2-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}benzoate

Base Information

Chemical Name:methyl 4-{[2-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}benzoate
CAS No.:909897-16-1
Molecular Formula:C₁₉H₁₆F₃N₃O₅S₂
Molecular Weight:487.48
Hs Code.:

Synonyms:methyl 4-{[2-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}benzoate

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Chemical Property of methyl 4-{[2-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}benzoate

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Technology Process of methyl 4-{[2-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}benzoate

There total 4 articles about methyl 4-{[2-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 907587-49-9
methyl 4-[(2-amino-5-(trifluoromethyl)phenoxy)methyl]benzoate

: 184222-90-0
5-methyl-1,3,4-thiadiazole-2-sulfonyl chloride

: 909897-16-1
methyl 4-{[2-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}benzoate

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃; for 4h;
DOI:10.1016/j.bmc.2006.05.076

Reference yield:

: 907587-46-6
methyl 4-[(2-nitro-5-(trifluoromethyl)phenoxy)methyl]benzoate

: 909897-16-1
methyl 4-{[2-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / iron; AcOH / H₂O / 0.5 h / 50 °C

2: 88 percent / pyridine / CH₂Cl₂ / 4 h / 20 °C

With pyridine; iron; acetic acid; In dichloromethane; water;
DOI:10.1016/j.bmc.2006.05.076

Reference yield:

: 402-54-0
p-nitrobenzotrifluoride

: 909897-16-1
methyl 4-{[2-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: 78 percent / potassium tert-butoxide; ammonia; tert-butyl hydroperoxide / decane; tetrahydrofuran / 0.5 h / Heating

2: 89 percent / K₂CO₃ / acetone / 3 h / 50 °C

3: 85 percent / iron; AcOH / H₂O / 0.5 h / 50 °C

4: 88 percent / pyridine / CH₂Cl₂ / 4 h / 20 °C

With pyridine; tert.-butylhydroperoxide; potassium tert-butylate; ammonia; iron; potassium carbonate; acetic acid; In tetrahydrofuran; decane; dichloromethane; water; acetone;
DOI:10.1016/j.bmc.2006.05.076