Technology Process of 3-hydroxy-13-(3-isopropoxy-4-methoxy-phenyl)-2,10,11-trimethoxy-5-oxa-6b-aza-dibenzo[a,i]fluoren-6-one
There total 11 articles about 3-hydroxy-13-(3-isopropoxy-4-methoxy-phenyl)-2,10,11-trimethoxy-5-oxa-6b-aza-dibenzo[a,i]fluoren-6-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 90 percent / aq. Na2CO3 / Pd(PPh3)4 / tetrahydrofuran / 20 h / Heating
2.1: 93 percent / cc.HCl / methanol / 2 h / Heating
3.1: aq. KOH / ethanol / 3 h / Heating
3.2: 77 percent / p-TsOH / CH2Cl2 / 1 h / Heating
4.1: 96 percent / Cu2O; quinoline / 0.17 h / 220 °C
5.1: 95 percent / phenyliodine bis(trifluoroacetate); BF3*Et2O / CH2Cl2 / 1.5 h / -40 °C
6.1: 99 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / CH2Cl2 / 30 h / Heating
7.1: 99 percent / H2 / Pd/C / ethyl acetate / 2 h / 20 °C
With
quinoline; copper(I) oxide; hydrogenchloride; potassium hydroxide; boron trifluoride diethyl etherate; hydrogen; sodium carbonate; 2,3-dicyano-5,6-dichloro-p-benzoquinone; bis-[(trifluoroacetoxy)iodo]benzene;
palladium on activated charcoal; tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl acetate;
1.1: Suzuki-Miyaura coupling;
DOI:10.1016/j.tetlet.2006.03.121
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 95 percent / phenyliodine bis(trifluoroacetate); BF3*Et2O / CH2Cl2 / 1.5 h / -40 °C
2: 99 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / CH2Cl2 / 30 h / Heating
3: 99 percent / H2 / Pd/C / ethyl acetate / 2 h / 20 °C
With
boron trifluoride diethyl etherate; hydrogen; 2,3-dicyano-5,6-dichloro-p-benzoquinone; bis-[(trifluoroacetoxy)iodo]benzene;
palladium on activated charcoal;
In
dichloromethane; ethyl acetate;
DOI:10.1016/j.tetlet.2006.03.121