3-hydroxy-13-(3-isopropoxy-4-methoxy-phenyl)-2,10,11-trimethoxy-5-oxa-6b-aza-dibenzo[a,i]fluoren-6-one

Base Information

Chemical Name:3-hydroxy-13-(3-isopropoxy-4-methoxy-phenyl)-2,10,11-trimethoxy-5-oxa-6b-aza-dibenzo[a,i]fluoren-6-one
CAS No.:895632-75-4
Molecular Formula:C₃₂H₂₉NO₈
Molecular Weight:555.584
Hs Code.:

3-hydroxy-13-(3-isopropoxy-4-methoxy-phenyl)-2,10,11-trimethoxy-5-oxa-6b-aza-dibenzo[<i>a</i>,<i>i</i>]fluoren-6-one

Synonyms:3-hydroxy-13-(3-isopropoxy-4-methoxy-phenyl)-2,10,11-trimethoxy-5-oxa-6b-aza-dibenzo[a,i]fluoren-6-one

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Chemical Property of 3-hydroxy-13-(3-isopropoxy-4-methoxy-phenyl)-2,10,11-trimethoxy-5-oxa-6b-aza-dibenzo[a,i]fluoren-6-one

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Technology Process of 3-hydroxy-13-(3-isopropoxy-4-methoxy-phenyl)-2,10,11-trimethoxy-5-oxa-6b-aza-dibenzo[a,i]fluoren-6-one

There total 11 articles about 3-hydroxy-13-(3-isopropoxy-4-methoxy-phenyl)-2,10,11-trimethoxy-5-oxa-6b-aza-dibenzo[a,i]fluoren-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 895632-67-4
20-benzyl-13-isopropyllamellarin α

: 895632-75-4
3-hydroxy-13-(3-isopropoxy-4-methoxy-phenyl)-2,10,11-trimethoxy-5-oxa-6b-aza-dibenzo[a,i]fluoren-6-one

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; at 20 ℃; for 2h;
DOI:10.1016/j.tetlet.2006.03.121

Reference yield:

: 895632-68-5
1-[2-(3,4-dimethoxy-phenyl)-ethyl]-3-(3-isopropoxy-4-methoxy-phenyl)-4-trifluoromethanesulfonyloxy-1H-pyrrole-2,5-dicarboxylic acid dimethyl ester

: 895632-75-4
3-hydroxy-13-(3-isopropoxy-4-methoxy-phenyl)-2,10,11-trimethoxy-5-oxa-6b-aza-dibenzo[a,i]fluoren-6-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: 90 percent / aq. Na₂CO₃ / Pd(PPh₃)4 / tetrahydrofuran / 20 h / Heating

2.1: 93 percent / cc.HCl / methanol / 2 h / Heating

3.1: aq. KOH / ethanol / 3 h / Heating

3.2: 77 percent / p-TsOH / CH₂Cl₂ / 1 h / Heating

4.1: 96 percent / Cu₂O; quinoline / 0.17 h / 220 °C

5.1: 95 percent / phenyliodine bis(trifluoroacetate); BF₃*Et₂O / CH₂Cl₂ / 1.5 h / -40 °C

6.1: 99 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / CH₂Cl₂ / 30 h / Heating

7.1: 99 percent / H₂ / Pd/C / ethyl acetate / 2 h / 20 °C

With quinoline; copper(I) oxide; hydrogenchloride; potassium hydroxide; boron trifluoride diethyl etherate; hydrogen; sodium carbonate; 2,3-dicyano-5,6-dichloro-p-benzoquinone; bis-[(trifluoroacetoxy)iodo]benzene; palladium on activated charcoal; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl acetate; 1.1: Suzuki-Miyaura coupling;
DOI:10.1016/j.tetlet.2006.03.121

Reference yield:

: 895632-73-2
7-benzyloxy-3-[2-(3,4-dimethoxy-phenyl)-ethyl]-1-(3-isopropoxy-4-methoxy-phenyl)-8-methoxy-3H-5-oxa-3-aza-cyclopenta[a]naphthalen-4-one

: 895632-75-4
3-hydroxy-13-(3-isopropoxy-4-methoxy-phenyl)-2,10,11-trimethoxy-5-oxa-6b-aza-dibenzo[a,i]fluoren-6-one

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / phenyliodine bis(trifluoroacetate); BF₃*Et₂O / CH₂Cl₂ / 1.5 h / -40 °C

2: 99 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / CH₂Cl₂ / 30 h / Heating

3: 99 percent / H₂ / Pd/C / ethyl acetate / 2 h / 20 °C

With boron trifluoride diethyl etherate; hydrogen; 2,3-dicyano-5,6-dichloro-p-benzoquinone; bis-[(trifluoroacetoxy)iodo]benzene; palladium on activated charcoal; In dichloromethane; ethyl acetate;
DOI:10.1016/j.tetlet.2006.03.121