cis-1-(methoxycarbonyl)-2-phenyl-3-cyano-4-hydroxy-1,2,3,4-tetrahydropyridine

Base Information

Chemical Name:cis-1-(methoxycarbonyl)-2-phenyl-3-cyano-4-hydroxy-1,2,3,4-tetrahydropyridine
CAS No.:87843-14-9
Molecular Formula:C₁₄H₁₄N₂O₃
Molecular Weight:258.277
Hs Code.:

Synonyms:cis-1-(methoxycarbonyl)-2-phenyl-3-cyano-4-hydroxy-1,2,3,4-tetrahydropyridine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of cis-1-(methoxycarbonyl)-2-phenyl-3-cyano-4-hydroxy-1,2,3,4-tetrahydropyridine

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Technology Process of cis-1-(methoxycarbonyl)-2-phenyl-3-cyano-4-hydroxy-1,2,3,4-tetrahydropyridine

There total 2 articles about cis-1-(methoxycarbonyl)-2-phenyl-3-cyano-4-hydroxy-1,2,3,4-tetrahydropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.4%

: 87843-06-9
3-(phenylsulfonyl)-4-phenyl-5-(methoxycarbonyl)-3a,4,5,7a-tetrahydropyrido<3,4-d>isoxazole

: 87843-14-9
cis-1-(methoxycarbonyl)-2-phenyl-3-cyano-4-hydroxy-1,2,3,4-tetrahydropyridine

Guidance literature:: With sodium tetrahydroborate; In methanol; at 0 ℃;
DOI:10.1021/jo00175a025

Reference yield:

: 54732-59-1
N-(methoxycarbonyl)-2-phenyl-1,2-dihydropyridine

: 87843-14-9
cis-1-(methoxycarbonyl)-2-phenyl-3-cyano-4-hydroxy-1,2,3,4-tetrahydropyridine

Guidance literature:: Multi-step reaction with 2 steps

1: 2) sodium metasilicate / 1.) methylene chloride, 30 min, cooling, 2.) 12 h, reflux

2: 17.4 percent / sodium borohydride / methanol / 0 °C

With sodium tetrahydroborate; sodium silicate; In methanol;
DOI:10.1021/jo00175a025