(2S)-[N-[(2S)-[(fluoren-9-ylmethoxy)carbonylamino]-5-[[imino[[(2,4,6-trimethylphenyl)sulfonyl]amino]methyl]amino]pentyl](phenylmethoxy)carbonylamino]-3-(2-naphthyl)propanoic acid

Base Information

Chemical Name:(2S)-[N-[(2S)-[(fluoren-9-ylmethoxy)carbonylamino]-5-[[imino[[(2,4,6-trimethylphenyl)sulfonyl]amino]methyl]amino]pentyl](phenylmethoxy)carbonylamino]-3-(2-naphthyl)propanoic acid
CAS No.:842166-64-7
Molecular Formula:C₅₁H₅₃N₅O₈S
Molecular Weight:896.077
Hs Code.:

(2S)-[N-[(2S)-[(fluoren-9-ylmethoxy)carbonylamino]-5-[[imino[[(2,4,6-trimethylphenyl)sulfonyl]amino]methyl]amino]pentyl](phenylmethoxy)carbonylamino]-3-(2-naphthyl)propanoic acid

Synonyms:(2S)-[N-[(2S)-[(fluoren-9-ylmethoxy)carbonylamino]-5-[[imino[[(2,4,6-trimethylphenyl)sulfonyl]amino]methyl]amino]pentyl](phenylmethoxy)carbonylamino]-3-(2-naphthyl)propanoic acid

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Chemical Property of (2S)-[N-[(2S)-[(fluoren-9-ylmethoxy)carbonylamino]-5-[[imino[[(2,4,6-trimethylphenyl)sulfonyl]amino]methyl]amino]pentyl](phenylmethoxy)carbonylamino]-3-(2-naphthyl)propanoic acid

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Technology Process of (2S)-[N-[(2S)-[(fluoren-9-ylmethoxy)carbonylamino]-5-[[imino[[(2,4,6-trimethylphenyl)sulfonyl]amino]methyl]amino]pentyl](phenylmethoxy)carbonylamino]-3-(2-naphthyl)propanoic acid

There total 9 articles about (2S)-[N-[(2S)-[(fluoren-9-ylmethoxy)carbonylamino]-5-[[imino[[(2,4,6-trimethylphenyl)sulfonyl]amino]methyl]amino]pentyl](phenylmethoxy)carbonylamino]-3-(2-naphthyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 82911-69-1
N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

: C₃₆H₄₃N₅O₆S

: 842166-64-7
(2S)-[N-[(2S)-[(fluoren-9-ylmethoxy)carbonylamino]-5-[[imino[[(2,4,6-trimethylphenyl)sulfonyl]amino]methyl]amino]pentyl](phenylmethoxy)carbonylamino]-3-(2-naphthyl)propanoic acid

Guidance literature:: With triethylamine; In tetrahydrofuran; water; at 20 ℃; for 8h;
DOI:10.1021/jm049429h

Reference yield:

: 68262-71-5,200122-85-6
Boc-Arg(MTS)-OH

: 842166-64-7
(2S)-[N-[(2S)-[(fluoren-9-ylmethoxy)carbonylamino]-5-[[imino[[(2,4,6-trimethylphenyl)sulfonyl]amino]methyl]amino]pentyl](phenylmethoxy)carbonylamino]-3-(2-naphthyl)propanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: 100 percent / potassium bicarbonate / dimethylformamide / 10 h / 20 °C

2.1: DIBAL-H / toluene; CH₂Cl₂ / 2 h / -78 °C

3.1: AcOH / 1,2-dichloro-ethane; dimethylformamide / 0.17 h / 4 °C

3.2: 3.4 g / NaBH(OAc)3 / 1,2-dichloro-ethane; dimethylformamide / 8 h / 20 °C

4.1: 77 percent / Et₃N / dimethylformamide / 8 h / 20 °C

5.1: TFA; anisole / 2 h / 20 °C

6.1: 1.39 g / Et₃N / tetrahydrofuran; H₂O / 8 h / 20 °C

With diisobutylaluminium hydride; potassium hydrogencarbonate; acetic acid; methoxybenzene; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm049429h

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 842166-64-7
(2S)-[N-[(2S)-[(fluoren-9-ylmethoxy)carbonylamino]-5-[[imino[[(2,4,6-trimethylphenyl)sulfonyl]amino]methyl]amino]pentyl](phenylmethoxy)carbonylamino]-3-(2-naphthyl)propanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 77 percent / Et₃N / dimethylformamide / 8 h / 20 °C

2: TFA; anisole / 2 h / 20 °C

3: 1.39 g / Et₃N / tetrahydrofuran; H₂O / 8 h / 20 °C

With methoxybenzene; triethylamine; trifluoroacetic acid; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1021/jm049429h