1-([N,N,-diisopropylamino]-2-cyanoethylphosphite)-2-O-(2-benzylcarbamate-3,4,6-tri-O-benzyl-2-deoxy-α-Dglucopyranosyl)-3-O-(4,4'-dimethoxytrityl)-sn-glycerol

Base Information

Chemical Name:1-([N,N,-diisopropylamino]-2-cyanoethylphosphite)-2-O-(2-benzylcarbamate-3,4,6-tri-O-benzyl-2-deoxy-α-Dglucopyranosyl)-3-O-(4,4'-dimethoxytrityl)-sn-glycerol
CAS No.:1354914-22-9
Molecular Formula:C₆₈H₇₈N₃O₁₂P
Molecular Weight:1160.35
Hs Code.:

1-([N,N,-diisopropylamino]-2-cyanoethylphosphite)-2-O-(2-benzylcarbamate-3,4,6-tri-O-benzyl-2-deoxy-α-Dglucopyranosyl)-3-O-(4,4'-dimethoxytrityl)-sn-glycerol

Synonyms:1-([N,N,-diisopropylamino]-2-cyanoethylphosphite)-2-O-(2-benzylcarbamate-3,4,6-tri-O-benzyl-2-deoxy-α-Dglucopyranosyl)-3-O-(4,4'-dimethoxytrityl)-sn-glycerol

Suppliers and Price of 1-([N,N,-diisopropylamino]-2-cyanoethylphosphite)-2-O-(2-benzylcarbamate-3,4,6-tri-O-benzyl-2-deoxy-α-Dglucopyranosyl)-3-O-(4,4'-dimethoxytrityl)-sn-glycerol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-([N,N,-diisopropylamino]-2-cyanoethylphosphite)-2-O-(2-benzylcarbamate-3,4,6-tri-O-benzyl-2-deoxy-α-Dglucopyranosyl)-3-O-(4,4'-dimethoxytrityl)-sn-glycerol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-([N,N,-diisopropylamino]-2-cyanoethylphosphite)-2-O-(2-benzylcarbamate-3,4,6-tri-O-benzyl-2-deoxy-α-Dglucopyranosyl)-3-O-(4,4'-dimethoxytrityl)-sn-glycerol

There total 8 articles about 1-([N,N,-diisopropylamino]-2-cyanoethylphosphite)-2-O-(2-benzylcarbamate-3,4,6-tri-O-benzyl-2-deoxy-α-Dglucopyranosyl)-3-O-(4,4'-dimethoxytrityl)-sn-glycerol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1354914-24-1
2-O-(2-benzylcarbamate-3,4,6-tri-O-benzyl-2-deoxy-α-D-glucopyranosyl)-3-O-(4,4'-dimethoxytrityl)-sn-glycerol

: 124482-92-4,89992-70-1
2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

: 1354914-22-9
1-([N,N,-diisopropylamino]-2-cyanoethylphosphite)-2-O-(2-benzylcarbamate-3,4,6-tri-O-benzyl-2-deoxy-α-Dglucopyranosyl)-3-O-(4,4'-dimethoxytrityl)-sn-glycerol

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; Inert atmosphere;
DOI:10.1021/ol2033652

Reference yield:

: 1354914-16-1
1-O-tert-butyldiphenylsilyl-2-O-(2-benzylcarbamate-3,4,6-tri-O-benzyl-2-deoxy-α-D-glucopyranosyl)-3-O-allyl-sn-glycerol

: 1354914-22-9
1-([N,N,-diisopropylamino]-2-cyanoethylphosphite)-2-O-(2-benzylcarbamate-3,4,6-tri-O-benzyl-2-deoxy-α-Dglucopyranosyl)-3-O-(4,4'-dimethoxytrityl)-sn-glycerol

Guidance literature:: Multi-step reaction with 4 steps

1.1: (1,5-cyclooctadiene)[bis(methyldiphenylphosphine)]iridium(I) hexafluorophosphate; hydrogen / tetrahydrofuran / 1.5 h / 20 °C / Inert atmosphere

1.2: 0.5 h / 20 °C / Inert atmosphere

2.1: triethylamine / dichloromethane / 2 h / 0 °C / Inert atmosphere

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

4.1: triethylamine / dichloromethane / 0 °C / Inert atmosphere

With (1,5-cyclooctadiene)[bis(methyldiphenylphosphine)]iridium(I) hexafluorophosphate; tetrabutyl ammonium fluoride; hydrogen; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol2033652

Reference yield:

: 1354914-20-7
1-O-tert-butyldiphenylsilyl-2-O-(2-benzylcarbamate-3,4,6-tri-O-benzyl-2-deoxy-α-D-glucopyranosyl)-sn-glycerol

: 1354914-22-9
1-([N,N,-diisopropylamino]-2-cyanoethylphosphite)-2-O-(2-benzylcarbamate-3,4,6-tri-O-benzyl-2-deoxy-α-Dglucopyranosyl)-3-O-(4,4'-dimethoxytrityl)-sn-glycerol

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 2 h / 0 °C / Inert atmosphere

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

3: triethylamine / dichloromethane / 0 °C / Inert atmosphere

With tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol2033652