4-benzoylamino-7-(2-desoxy-β-D-erythro-pentofuranosyl)-3'-O-(diisopropylmethylphosphoramidito)-5'-O-(4,4'-dimethoxytrityl)-7H-pyrrolo-<2,3-d>pyrimidin

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Chemical Name:4-benzoylamino-7-(2-desoxy-β-D-erythro-pentofuranosyl)-3'-O-(diisopropylmethylphosphoramidito)-5'-O-(4,4'-dimethoxytrityl)-7H-pyrrolo-<2,3-d>pyrimidin
CAS No.:98921-82-5
Molecular Formula:C₄₆H₅₂N₅O₇P
Molecular Weight:817.922
Hs Code.:

4-benzoylamino-7-(2-desoxy-β-D-erythro-pentofuranosyl)-3'-O-(diisopropylmethylphosphoramidito)-5'-O-(4,4'-dimethoxytrityl)-7H-pyrrolo-<2,3-d>pyrimidin

Synonyms:4-benzoylamino-7-(2-desoxy-β-D-erythro-pentofuranosyl)-3'-O-(diisopropylmethylphosphoramidito)-5'-O-(4,4'-dimethoxytrityl)-7H-pyrrolo-<2,3-d>pyrimidin

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Chemical Property of 4-benzoylamino-7-(2-desoxy-β-D-erythro-pentofuranosyl)-3'-O-(diisopropylmethylphosphoramidito)-5'-O-(4,4'-dimethoxytrityl)-7H-pyrrolo-<2,3-d>pyrimidin

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

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Technology Process of 4-benzoylamino-7-(2-desoxy-β-D-erythro-pentofuranosyl)-3'-O-(diisopropylmethylphosphoramidito)-5'-O-(4,4'-dimethoxytrityl)-7H-pyrrolo-<2,3-d>pyrimidin

There total 4 articles about 4-benzoylamino-7-(2-desoxy-β-D-erythro-pentofuranosyl)-3'-O-(diisopropylmethylphosphoramidito)-5'-O-(4,4'-dimethoxytrityl)-7H-pyrrolo-<2,3-d>pyrimidin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 86030-43-5
N,N-diisopropylmethylphosphonamidic chloride

: 90335-57-2
N-(7-((2R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxytetrahydrofuran-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)benzamide

: 98921-82-5
4-benzoylamino-7-(2-desoxy-β-D-erythro-pentofuranosyl)-3'-O-(diisopropylmethylphosphoramidito)-5'-O-(4,4'-dimethoxytrityl)-7H-pyrrolo-<2,3-d>pyrimidin

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 2h; Ambient temperature;
DOI:10.1016/S0040-4020(01)96795-X

Reference yield:

: 95261-09-9
4-benzoylamino-7-(2-desoxy-β-Derythro-pentofuranosyl)-7H-pyrrolo<2,3-d> yrimidin

: 98921-82-5
4-benzoylamino-7-(2-desoxy-β-D-erythro-pentofuranosyl)-3'-O-(diisopropylmethylphosphoramidito)-5'-O-(4,4'-dimethoxytrityl)-7H-pyrrolo-<2,3-d>pyrimidin

Guidance literature:: Multi-step reaction with 2 steps

1: 76 percent / N-ethyldiisopropylamine / pyridine / 3 h / Ambient temperature

2: 72 percent / N-ethyldiisopropylamin, / CH₂Cl₂ / 2 h / Ambient temperature

With N-ethyl-N,N-diisopropylamine; In pyridine; dichloromethane;
DOI:10.1016/S0040-4020(01)96795-X

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 98921-82-5
4-benzoylamino-7-(2-desoxy-β-D-erythro-pentofuranosyl)-3'-O-(diisopropylmethylphosphoramidito)-5'-O-(4,4'-dimethoxytrityl)-7H-pyrrolo-<2,3-d>pyrimidin

Guidance literature:: Multi-step reaction with 2 steps

1: 76 percent / N-ethyldiisopropylamine / pyridine / 3 h / Ambient temperature

2: 72 percent / N-ethyldiisopropylamin, / CH₂Cl₂ / 2 h / Ambient temperature

With N-ethyl-N,N-diisopropylamine; In pyridine; dichloromethane;
DOI:10.1016/S0040-4020(01)96795-X