3-{3-(2-benzyloxyethyl)-1-[2-(1-methyl-1H-indol-3-yl)acetyl]-2-oxopiperidin-3-yl}-2-diazo-3-oxopropionic acid methyl ester

Base Information

Chemical Name:3-{3-(2-benzyloxyethyl)-1-[2-(1-methyl-1H-indol-3-yl)acetyl]-2-oxopiperidin-3-yl}-2-diazo-3-oxopropionic acid methyl ester
CAS No.:934586-55-7
Molecular Formula:C₂₉H₃₀N₄O₆
Molecular Weight:530.58
Hs Code.:

Synonyms:3-{3-(2-benzyloxyethyl)-1-[2-(1-methyl-1H-indol-3-yl)acetyl]-2-oxopiperidin-3-yl}-2-diazo-3-oxopropionic acid methyl ester

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Chemical Property of 3-{3-(2-benzyloxyethyl)-1-[2-(1-methyl-1H-indol-3-yl)acetyl]-2-oxopiperidin-3-yl}-2-diazo-3-oxopropionic acid methyl ester

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Technology Process of 3-{3-(2-benzyloxyethyl)-1-[2-(1-methyl-1H-indol-3-yl)acetyl]-2-oxopiperidin-3-yl}-2-diazo-3-oxopropionic acid methyl ester

There total 3 articles about 3-{3-(2-benzyloxyethyl)-1-[2-(1-methyl-1H-indol-3-yl)acetyl]-2-oxopiperidin-3-yl}-2-diazo-3-oxopropionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 934586-54-6
C₁₈H₂₁N₃O₅

: 104819-31-0
1-methylindole-3-acetic acid chloride

: 934586-55-7
3-{3-(2-benzyloxyethyl)-1-[2-(1-methyl-1H-indol-3-yl)acetyl]-2-oxopiperidin-3-yl}-2-diazo-3-oxopropionic acid methyl ester

Guidance literature:: With 4 A molecular sieve; In tetrahydrofuran; for 12h;
DOI:10.1055/s-2007-967982

Reference yield:

: 915706-92-2
3-[3-{2-benzyloxyethyl}-2-oxo-piperidin-3-yl]-3-oxo-propionic acid methyl ester

: 934586-55-7
3-{3-(2-benzyloxyethyl)-1-[2-(1-methyl-1H-indol-3-yl)acetyl]-2-oxopiperidin-3-yl}-2-diazo-3-oxopropionic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: MsN₃; Et₃N

2: 82 percent / molecular sieves 4 Angstroem / tetrahydrofuran / 12 h

With 4 A molecular sieve; triethylamine; Methanesulfonyl azide; In tetrahydrofuran;
DOI:10.1055/s-2007-967982

Reference yield:

: 1912-48-7
2-(1-methyl-1H-indol-3-yl)acetic acid

: 934586-55-7
3-{3-(2-benzyloxyethyl)-1-[2-(1-methyl-1H-indol-3-yl)acetyl]-2-oxopiperidin-3-yl}-2-diazo-3-oxopropionic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl chloride / CH₂Cl₂

2: 82 percent / molecular sieves 4 Angstroem / tetrahydrofuran / 12 h

With oxalyl dichloride; 4 A molecular sieve; In tetrahydrofuran; dichloromethane;
DOI:10.1055/s-2007-967982