N-[2-(4,5-dimethoxy-2-styrylphenyl)ethyl]carbamic acid ethyl ester

Base Information

• Chemical Name: N-[2-(4,5-dimethoxy-2-styrylphenyl)ethyl]carbamic acid ethyl ester
• CAS No.: 343780-62-1
• Molecular Formula: C₂₁H₂₅NO₄
• Molecular Weight: 355.434
• Mol file: 343780-62-1.mol

Synonyms:N-[2-(4,5-dimethoxy-2-styrylphenyl)ethyl]carbamic acid ethyl ester

Chemical Property of N-[2-(4,5-dimethoxy-2-styrylphenyl)ethyl]carbamic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of N-[2-(4,5-dimethoxy-2-styrylphenyl)ethyl]carbamic acid ethyl ester

There total 4 articles about N-[2-(4,5-dimethoxy-2-styrylphenyl)ethyl]carbamic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + N-[2-(2-iodo-4,5-dimethoxyphenyl)ethyl]carbamic acid ethyl ester (343780-59-6) → N-[2-(4,5-dimethoxy-2-styrylphenyl)ethyl]carbamic acid ethyl ester (343780-62-1) + {2-[4,5-dimethoxy-2-(1-phenyl-vinyl)-phenyl]-ethyl}-carbamic acid ethyl ester

Guidance literature:

With triethylamine; triphenylphosphine; palladium diacetate; In acetonitrile; at 80 ℃; for 24h;

DOI:10.1016/S0040-4020(03)01135-9

Reference yield: 70.0%

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + N-[2-(2-iodo-4,5-dimethoxyphenyl)ethyl]carbamic acid ethyl ester (343780-59-6) → N-[2-(4,5-dimethoxy-2-styrylphenyl)ethyl]carbamic acid ethyl ester (343780-62-1)

Guidance literature:

With palladium diacetate; triethylamine; triphenylphosphine; In acetonitrile; at 80 ℃; for 24h;

DOI:10.1016/S0040-4039(01)00168-X

Reference yield:

N-<2-(3,4-Dimethoxyphenyl)ethyl>carbamidsaeureethylester (17889-63-3) → N-[2-(4,5-dimethoxy-2-styrylphenyl)ethyl]carbamic acid ethyl ester (343780-62-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 99 percent / trifluoromethanesulfonic acid; IPy₂BF₄ / CH₂Cl₂ / 0.5 h / 0 °C

2: 70 percent / PPh₃; triethylamine / Pd(OAc)2 / acetonitrile / 24 h / 80 °C

With Barluenga reagent; trifluorormethanesulfonic acid; triethylamine; triphenylphosphine; palladium diacetate; In dichloromethane; acetonitrile; 2: Heck coupling;

DOI:10.1016/S0040-4020(03)01135-9

upstream raw materials:

styrene

N-[2-(2-iodo-4,5-dimethoxyphenyl)ethyl]carbamic acid ethyl ester

N-<2-(3,4-Dimethoxyphenyl)ethyl>carbamidsaeureethylester

2-(3,4-dimethoxyphenyl)-ethylamine

Downstream raw materials:

N-[2-(4,5-dimethoxy-2-styrylphenyl)ethyl]-N-methylcarbamic acid ethyl ester

7,8-dimethoxy-2-methyl-5-styryl-3,4-dihydro-2H-isoquinolin-1-one